Reactome Pathway Database

Schema > Reaction > Entries

PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine Show undefined attributes

catalystActivity

[CatalystActivity:10093046] calcium-dependent phospholipase A2 activity of Active PLA2:phosphatidylcholine [endoplasmic reticulum membrane]

category transition

compartment

created [InstanceEdit:10084857] Weiser, Joel, 2025年08月27日

dbId 10093048

displayName PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine

eventOf

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

inferredFrom

[Reaction:R-HSA-111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine
1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H+

output

precedingEvent

[Reaction:R-RNO-111881] Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase - Rattus norvegicus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48895] Rattus norvegicus

stId R-RNO-111883

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

(precedingEvent)

(inferredTo)

[Reaction:R-HSA-111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine

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