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Schema
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Reaction
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Entries
PTPN6 dephosphorylates JAK3
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authored
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
catalystActivity
[CatalystActivity:210267] protein tyrosine phosphatase activity of PTPN6 [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9701509] Rothfels, Karen, 2020年09月26日
dbId
9701507
displayName
PTPN6 dephosphorylates JAK3
edited
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
eventOf
[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
input
[Complex:R-HSA-9701475] Active ALK:p-Y980 JAK3 [plasma membrane]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9701413] Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma
[LiteratureReference:9701348] Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma
[LiteratureReference:9699641] Anaplastic lymphoma kinase: signalling in development and disease
[LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer
[LiteratureReference:9701407] Methylation of SHP1 gene and loss of SHP1 protein expression are frequent in systemic anaplastic large cell lymphoma
maxDepth
1
modified
[InstanceEdit:10424722] Weiser, Joel, 2025年08月27日
name
PTPN6 dephosphorylates JAK3
orthologousEvent
[Reaction:R-SSC-9701507] PTPN6 dephosphorylates JAK3 - Sus scrofa
[Reaction:R-BTA-9701507] PTPN6 dephosphorylates JAK3 - Bos taurus
[Reaction:R-CFA-9701507] PTPN6 dephosphorylates JAK3 - Canis familiaris
[Reaction:R-RNO-9701507] PTPN6 dephosphorylates JAK3 - Rattus norvegicus
[Reaction:R-MMU-9701507] PTPN6 dephosphorylates JAK3 - Mus musculus
output
[Complex:R-HSA-9701478] Active ALK:JAK3 [plasma membrane]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent
[Reaction:R-HSA-9701488] Active ALK phosphorylates JAK3 - Homo sapiens
releaseDate
2021年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9729891] Inghirami, Giorgio, 2021年05月04日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9701507
summation
[Summation:9701508] PTPN6, also known as SHP1, dephosphorylates JAK3 downstream ...
Referrals
(hasEvent)
[Pathway:R-HSA-201556] Signaling by ALK
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