Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
Active ALK phosphorylates JAK3
Show undefined attributes
Go to Details
authored
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
catalystActivity
[CatalystActivity:9701490] protein tyrosine kinase activity of Active ALK:JAK3 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:9701491] Rothfels, Karen, 2020年09月26日
dbId
9701488
displayName
Active ALK phosphorylates JAK3
edited
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
eventOf
[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
followingEvent
[Reaction:R-HSA-9701507] PTPN6 dephosphorylates JAK3 - Homo sapiens
input
[Complex:R-HSA-9701478] Active ALK:JAK3 [plasma membrane]
[SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9701321] Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
[LiteratureReference:9701338] Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma
[LiteratureReference:9701408] Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma
[LiteratureReference:9701413] Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma
[LiteratureReference:9701348] Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma
[LiteratureReference:9701315] JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells
[LiteratureReference:9699641] Anaplastic lymphoma kinase: signalling in development and disease
maxDepth
1
modified
[InstanceEdit:10424722] Weiser, Joel, 2025年08月27日
name
Active ALK phosphorylates JAK3
orthologousEvent
[Reaction:R-SSC-9701488] Active ALK phosphorylates JAK3 - Sus scrofa
[Reaction:R-BTA-9701488] Active ALK phosphorylates JAK3 - Bos taurus
[Reaction:R-CFA-9701488] Active ALK phosphorylates JAK3 - Canis familiaris
[Reaction:R-RNO-9701488] Active ALK phosphorylates JAK3 - Rattus norvegicus
[Reaction:R-MMU-9701488] Active ALK phosphorylates JAK3 - Mus musculus
output
[Complex:R-HSA-9701475] Active ALK:p-Y980 JAK3 [plasma membrane]
[SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent
[Reaction:R-HSA-9701485] Active ALK binds JAK3 - Homo sapiens
releaseDate
2021年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9729891] Inghirami, Giorgio, 2021年05月04日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9701488
summation
[Summation:9701489] JAK3 is phosphorylated downstream of active ALK signaling (Z...
Referrals
(hasEvent)
[Pathway:R-HSA-201556] Signaling by ALK
(precedingEvent)
[Reaction:R-HSA-9701507] PTPN6 dephosphorylates JAK3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル