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Go!
Schema
>
DefinedSet
>
Entries
NVP-TAE684-resistant ALK mutants [plasma membrane]
Show undefined attributes
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compartment
[Compartment:876] plasma membrane
consumedByEvent
[FailedReaction:R-HSA-9700114] NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 - Homo sapiens
created
[InstanceEdit:9700562] Rothfels, Karen, 2020年09月16日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9700568
disease
[Disease:1500689] cancer
displayName
NVP-TAE684-resistant ALK mutants [plasma membrane]
hasMember
[Complex:R-HSA-9701839] ALK L1152R dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9700533] ALK I1171N dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9701840] ALK L1198P dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9701827] ALK D1203N dimer [plasma membrane] - Homo sapiens
[Complex:R-HSA-9700557] ALK A1234T dimer [plasma membrane] - Homo sapiens
inDisease
true
literatureReference
[LiteratureReference:9700412] Activating mutations in ALK provide a therapeutic target in neuroblastoma
[LiteratureReference:9701779] A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors
[LiteratureReference:9701773] ALK mutations conferring differential resistance to structurally diverse ALK inhibitors
[LiteratureReference:9700339] Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors
[LiteratureReference:9717267] TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors
maxDepth
3
modified
[InstanceEdit:9757297] Rothfels, Karen, 2021年10月28日
name
NVP-TAE684-resistant ALK mutants
schemaClass
DefinedSet
species
[Species:48887] Homo sapiens
stId
R-HSA-9700568
Referrals
(input)
[FailedReaction:R-HSA-9700114] NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684
(diseaseEntity)
[EntityFunctionalStatus:9717337] loss_of_function of NVP-TAE684-resistant ALK mutants [plasma membrane]
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