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Schema
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FailedReaction
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Entries
NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684
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authored
[InstanceEdit:9724129] Rothfels, Karen, 2021年03月22日
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:9700115] Rothfels, Karen, 2020年09月14日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9700114
disease
[Disease:1500689] cancer
displayName
NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684
edited
[InstanceEdit:9725664] Rothfels, Karen, 2021年03月30日
entityFunctionalStatus
[EntityFunctionalStatus:9717337] loss_of_function of NVP-TAE684-resistant ALK mutants [plasma membrane]
eventOf
[Pathway:R-HSA-9717301] NVP-TAE684-resistant ALK mutants - Homo sapiens
input
[ChemicalDrug:R-ALL-9699607] NVP-TAE684 [cytosol]
[DefinedSet:R-HSA-9700568] NVP-TAE684-resistant ALK mutants [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9701779] A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors
[LiteratureReference:9700339] Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors
[LiteratureReference:9701773] ALK mutations conferring differential resistance to structurally diverse ALK inhibitors
[LiteratureReference:9700412] Activating mutations in ALK provide a therapeutic target in neuroblastoma
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684
normalReaction
[Reaction:R-HSA-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs
releaseDate
2021年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9729891] Inghirami, Giorgio, 2021年05月04日
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9700114
summation
[Summation:9715235] The following ALK mutants are resistant to inhibiton by NVP-...
Referrals
(hasEvent)
[Pathway:R-HSA-9717301] NVP-TAE684-resistant ALK mutants
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