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Schema
>
DefinedSet
>
Entries
quizartinib-resistant FLT3 mutants [plasma membrane]
Show undefined attributes
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compartment
[Compartment:876] plasma membrane
consumedByEvent
[FailedReaction:R-HSA-9702618] quizartinib-resistant FLT3 mutants don't bind quizartinib - Homo sapiens
created
[InstanceEdit:9699524] Rothfels, Karen, 2020年09月14日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9699525
disease
[Disease:1500689] cancer
displayName
quizartinib-resistant FLT3 mutants [plasma membrane]
hasMember
[EntityWithAccessionedSequence:R-HSA-9699448] FLT3 A627P [plasma membrane] - Homo sapiens
[EntityWithAccessionedSequence:R-HSA-9702895] FLT3 N676D [plasma membrane] - Homo sapiens
[EntityWithAccessionedSequence:R-HSA-9702900] FLT3 F691I [plasma membrane] - Homo sapiens
[EntityWithAccessionedSequence:R-HSA-9695722] FLT3 F691L [plasma membrane] - Homo sapiens
[EntityWithAccessionedSequence:R-HSA-9682313] FLT3 D835F [plasma membrane] - Homo sapiens
[EntityWithAccessionedSequence:R-HSA-9682304] FLT3 D835H [plasma membrane] - Homo sapiens
[EntityWithAccessionedSequence:R-HSA-9682323] FLT3 D835V [plasma membrane] - Homo sapiens
[EntityWithAccessionedSequence:R-HSA-9682353] FLT3 D835Y [plasma membrane] - Homo sapiens
[EntityWithAccessionedSequence:R-HSA-9695715] FLT3 D835del [plasma membrane] - Homo sapiens
[EntityWithAccessionedSequence:R-HSA-9699435] FLT3 Y842C [plasma membrane] - Homo sapiens
[EntityWithAccessionedSequence:R-HSA-9699443] FLT3 Y842H [plasma membrane] - Homo sapiens
[EntityWithAccessionedSequence:R-HSA-9702909] FLT3 A848P [plasma membrane] - Homo sapiens
inDisease
true
literatureReference
[LiteratureReference:9699248] Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants
[LiteratureReference:9699345] Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors
[LiteratureReference:9699384] The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vitro sensitivity to PKC412 and Sunitinib
[LiteratureReference:9699279] FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitors
[LiteratureReference:9695648] Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD
[LiteratureReference:9699393] Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia
[LiteratureReference:9699271] Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia
maxDepth
2
modified
[InstanceEdit:9703081] Rothfels, Karen, 2020年10月05日
name
quizartinib-resistant FLT3 mutants
schemaClass
DefinedSet
species
[Species:48887] Homo sapiens
stId
R-HSA-9699525
Referrals
(input)
[FailedReaction:R-HSA-9702618] quizartinib-resistant FLT3 mutants don't bind quizartinib
(diseaseEntity)
[EntityFunctionalStatus:9702619] loss_of_function of quizartinib-resistant FLT3 mutants [plasma membrane]
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