Reactome Pathway Database

Schema > EntityWithAccessionedSequence > Entries

FLT3 D835Y [plasma membrane] Show undefined attributes

compartment

[Compartment:876] plasma membrane

componentOf

created [InstanceEdit:9682352] Rothfels, Karen, 2020年04月08日

crossReference

dbId 9682353

disease

displayName FLT3 D835Y [plasma membrane]

endCoordinate 993

hasModifiedResidue

[ReplacedResidue:9682350] L-aspartic acid 835 replaced with L-tyrosine

inDisease true

literatureReference

[LiteratureReference:9682272] Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
[LiteratureReference:9695676] Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518

maxDepth 1

memberOf

modified [InstanceEdit:9695710] Rothfels, Karen, 2020年07月15日

name

FLT3 D835Y
STK-1

referenceEntity [ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3

referenceType ReferenceGeneProduct

schemaClass EntityWithAccessionedSequence

species [Species:48887] Homo sapiens

stId R-HSA-9682353

startCoordinate 27

Referrals

(hasMember)

(hasComponent)

[Complex:R-HSA-9682356] FLT3 D835Y dimer [plasma membrane]

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