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RAB GEFs exchange GTP for GDP on RABs
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authored
[InstanceEdit:8878001] Rothfels, Karen, 2016年06月28日
created
[InstanceEdit:8876197] Rothfels, Karen, 2016年06月09日
dbId
8876198
displayName
RAB GEFs exchange GTP for GDP on RABs
doi
10.3180/R-HSA-8876198.1
edited
[InstanceEdit:8878001] Rothfels, Karen, 2016年06月28日
eventOf
[Pathway:R-HSA-9007101] Rab regulation of trafficking - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-8877475] TRAPPC complexes exchange GTP for GDP on RAB1 - Homo sapiens
[Reaction:R-HSA-8875318] RAB3 GEFs exchange GTP for GDP on RAB3A - Homo sapiens
[Reaction:R-HSA-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Homo sapiens
[Reaction:R-HSA-8876193] RIC1-RGP1 exchanges GTP for GDP on RAB6 - Homo sapiens
[Reaction:R-HSA-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Homo sapiens
[Reaction:R-HSA-8876190] RAB8 GEFs exchange GTP for GDP on RAB8 - Homo sapiens
[Reaction:R-HSA-8876191] RAB9 GEFs exchange GTP for GDP on RAB9 - Homo sapiens
[Reaction:R-HSA-8876188] DENND4s exchange GTP for GDP on RAB10 - Homo sapiens
[Reaction:R-HSA-8876446] p-ULK1 phosphorylates DENND3 - Homo sapiens
[Reaction:R-HSA-8876454] DENND3 exchanges GTP for GDP on RAB12 - Homo sapiens
[Reaction:R-HSA-8876615] RAB13 GEFs exchange GTP for GDP on RAB13 - Homo sapiens
[Reaction:R-HSA-8876616] DENND6A,B exchange GTP for GDP on RAB14 - Homo sapiens
[Reaction:R-HSA-8876837] RAB21 GEFs exchange GTP for GDP on RAB21 - Homo sapiens
[Reaction:R-HSA-8877308] MADD exchanges GTP for GDP on RAB27 - Homo sapiens
[Reaction:R-HSA-8877311] RAB31 GEFs exchange GTP for GDP on RAB31 - Homo sapiens
[Reaction:R-HSA-8933446] Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling - Homo sapiens
[Reaction:R-HSA-8933452] YWHAE dimer binds phosphorylated DENND1 proteins - Homo sapiens
[Reaction:R-HSA-8877612] DENND1s exchange GTP for GDP on RAB35 - Homo sapiens
[Reaction:R-HSA-8877760] HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38 - Homo sapiens
[Reaction:R-HSA-8877813] DENND5A,B exchange GTP for GDP on RAB39 - Homo sapiens
[Reaction:R-HSA-8877998] RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18 - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8855098] Rab GTPases as coordinators of vesicle traffic
[LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
[LiteratureReference:8875688] Hypervariable C-terminal domain of rab proteins acts as a targeting signal
[LiteratureReference:8874657] Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins
[LiteratureReference:8874646] Membrane targeting of the small GTPase Rab9 is accompanied by nucleotide exchange
[LiteratureReference:6801137] Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A
[LiteratureReference:8874649] Nucleotide dependence of Rab geranylgeranylation. Rab escort protein interacts preferentially with GDP-bound Rab
[LiteratureReference:8875709] Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes
[LiteratureReference:8875704] Membrane extraction of Rab proteins by GDP dissociation inhibitor characterized using attenuated total reflection infrared spectroscopy
[LiteratureReference:8855099] TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism
[LiteratureReference:8855100] Illuminating the functional and structural repertoire of human TBC/RABGAPs
[LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases
[LiteratureReference:8874103] Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes
[LiteratureReference:8874101] Mechanism of digeranylgeranylation of Rab proteins. Formation of a complex between monogeranylgeranyl-Rab and Rab escort protein
[LiteratureReference:8870364] Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein
[LiteratureReference:8875710] Protein prenylation: enzymes, therapeutics, and biotechnology applications
[LiteratureReference:6801102] Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate
[LiteratureReference:8875714] Yip3 catalyses the dissociation of endosomal Rab-GDI complexes
[LiteratureReference:8867347] TBC proteins: GAPs for mammalian small GTPase Rab?
[LiteratureReference:5672281] Regulation of small GTPases by GEFs, GAPs, and GDIs
[LiteratureReference:8877950] Rab GEFs and GAPs
[LiteratureReference:8877631] DENN domain proteins: regulators of Rab GTPases
maxDepth
2
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
RAB GEFs exchange GTP for GDP on RABs
orthologousEvent
[Pathway:R-PFA-8876198] RAB GEFs exchange GTP for GDP on RABs - Plasmodium falciparum
[Pathway:R-SCE-8876198] RAB GEFs exchange GTP for GDP on RABs - Saccharomyces cerevisiae
[Pathway:R-SPO-8876198] RAB GEFs exchange GTP for GDP on RABs - Schizosaccharomyces pombe
[Pathway:R-DDI-8876198] RAB GEFs exchange GTP for GDP on RABs - Dictyostelium discoideum
[Pathway:R-CEL-8876198] RAB GEFs exchange GTP for GDP on RABs - Caenorhabditis elegans
[Pathway:R-DME-8876198] RAB GEFs exchange GTP for GDP on RABs - Drosophila melanogaster
[Pathway:R-GGA-8876198] RAB GEFs exchange GTP for GDP on RABs - Gallus gallus
[Pathway:R-XTR-8876198] RAB GEFs exchange GTP for GDP on RABs - Xenopus tropicalis
[Pathway:R-DRE-8876198] RAB GEFs exchange GTP for GDP on RABs - Danio rerio
[Pathway:R-MMU-8876198] RAB GEFs exchange GTP for GDP on RABs - Mus musculus
[Pathway:R-RNO-8876198] RAB GEFs exchange GTP for GDP on RABs - Rattus norvegicus
[Pathway:R-CFA-8876198] RAB GEFs exchange GTP for GDP on RABs - Canis familiaris
[Pathway:R-BTA-8876198] RAB GEFs exchange GTP for GDP on RABs - Bos taurus
[Pathway:R-SSC-8876198] RAB GEFs exchange GTP for GDP on RABs - Sus scrofa
releaseDate
2016年09月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8933218] Marat, Andrea L, 2016年08月03日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-8876198
summation
[Summation:8878000] Human cells have more than 60 RAB proteins that are key regu...
Referrals
(hasEvent)
[Pathway:R-HSA-9007101] Rab regulation of trafficking
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