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Schema
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Reaction
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Entries
MON1:CCZ1 exchanges GTP for GDP on RAB7
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authored
[InstanceEdit:8878001] Rothfels, Karen, 2016年06月28日
catalystActivity
[CatalystActivity:8877445] guanyl-nucleotide exchange factor activity of MON1:CCZ1 [cytosol]
category
transition
compartment
[Compartment:17938] lysosomal membrane
[Compartment:70101] cytosol
created
[InstanceEdit:8877452] Rothfels, Karen, 2016年06月22日
dbId
8877451
displayName
MON1:CCZ1 exchanges GTP for GDP on RAB7
edited
[InstanceEdit:8878001] Rothfels, Karen, 2016年06月28日
eventOf
[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs - Homo sapiens
input
[Complex:R-HSA-8877449] GGC-RAB7:GDP:GDIs,CHMs [cytosol]
[SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8871102] Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments
[LiteratureReference:8877540] Rab 7: an important regulator of late endocytic membrane traffic
[LiteratureReference:8877590] Role of the small GTPase Rab7 in the late endocytic pathway
[LiteratureReference:8877534] Membrane dynamics and fusion at late endosomes and vacuoles--Rab regulation, multisubunit tethering complexes and SNAREs
[LiteratureReference:8877550] Tethering complexes in the endocytic pathway: CORVET and HOPS
[LiteratureReference:8877563] The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7
[LiteratureReference:8877519] BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor
[LiteratureReference:8877528] Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells
[LiteratureReference:8877555] The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways
[LiteratureReference:8877523] Identification of the switch in early-to-late endosome transition
[LiteratureReference:8877520] CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion
[LiteratureReference:8877568] Rab7: role of its protein interaction cascades in endo-lysosomal traffic
[LiteratureReference:2028856] Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP
[LiteratureReference:8877548] Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes
[LiteratureReference:8877586] Rab7 is required for the normal progression of the autophagic pathway in mammalian cells
[LiteratureReference:8877577] Maturation of autophagosomes and endosomes: a key role for Rab7
[LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases
[LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
MON1:CCZ1 exchanges GTP for GDP on RAB7
orthologousEvent
[Reaction:R-PFA-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Plasmodium falciparum
[Reaction:R-SCE-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Saccharomyces cerevisiae
[Reaction:R-DDI-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Dictyostelium discoideum
[Reaction:R-CEL-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Caenorhabditis elegans
[Reaction:R-DME-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Drosophila melanogaster
[Reaction:R-GGA-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Gallus gallus
[Reaction:R-SSC-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Sus scrofa
[Reaction:R-BTA-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Bos taurus
[Reaction:R-CFA-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Canis familiaris
[Reaction:R-RNO-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Rattus norvegicus
[Reaction:R-MMU-8877451] MON1:CCZ1 exchanges GTP for GDP on RAB7 - Mus musculus
output
[DefinedSet:R-HSA-8875305] GDIs,CHMs [cytosol]
[SimpleEntity:R-ALL-29420] GDP [cytosol]
[Complex:R-HSA-8877453] GGC-RAB7:GTP [lysosomal membrane]
releaseDate
2016年09月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8933218] Marat, Andrea L, 2016年08月03日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8877451
summation
[Summation:8877570] RAB7 acts downstream of RAB5 in a RAB cascade that regulates...
Referrals
(hasEvent)
[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs
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