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Schema
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Reaction
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Entries
RAB13 GEFs exchange GTP for GDP on RAB13
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authored
[InstanceEdit:8878001] Rothfels, Karen, 2016年06月28日
catalystActivity
[CatalystActivity:8876610] guanyl-nucleotide exchange factor activity of RAB13 GEFs [cytosol]
category
transition
compartment
[Compartment:204883] cell junction
[Compartment:70101] cytosol
created
[InstanceEdit:8876613] Rothfels, Karen, 2016年06月15日
dbId
8876615
displayName
RAB13 GEFs exchange GTP for GDP on RAB13
edited
[InstanceEdit:8878001] Rothfels, Karen, 2016年06月28日
eventOf
[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs - Homo sapiens
input
[Complex:R-HSA-8876604] GGC-RAB13:GDP:GDIs,CHMs [cytosol]
[SimpleEntity:R-ALL-29438] GTP [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8876526] The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells
[LiteratureReference:8876545] Rab13 regulates PKA signaling during tight junction assembly
[LiteratureReference:8876546] Rab13 mediates the continuous endocytic recycling of occludin to the cell surface
[LiteratureReference:8876565] JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin
[LiteratureReference:8876529] The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions
[LiteratureReference:8876541] Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells
[LiteratureReference:1449646] Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells
[LiteratureReference:8876536] Rab13 regulates neurite outgrowth in PC12 cells through its effector protein, JRAB/MICAL-L2
[LiteratureReference:8876556] Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking
[LiteratureReference:8876583] A complex of Rab13 with MICAL-L2 and ?-actinin-4 is essential for insulin-dependent GLUT4 exocytosis
[LiteratureReference:8876517] Transcript profiling in peripheral T-cell lymphoma, not otherwise specified, and diffuse large B-cell lymphoma identifies distinct tumor profile signatures
[LiteratureReference:8876578] Bioinformatics analysis reveals disturbance mechanism of MAPK signaling pathway and cell cycle in Glioblastoma multiforme
[LiteratureReference:8876570] DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior
[LiteratureReference:8876534] Regulation of Cancer Cell Behavior by the Small GTPase Rab13
[LiteratureReference:2457791] Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors
[LiteratureReference:8876575] Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton
[LiteratureReference:8877734] Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases
[LiteratureReference:8871106] Rab proteins and the compartmentalization of the endosomal system
maxDepth
1
modified
[InstanceEdit:10948619] Weiser, Joel, 2025年08月27日
name
RAB13 GEFs exchange GTP for GDP on RAB13
orthologousEvent
[Reaction:R-DDI-8876615] RAB13 GEFs exchange GTP for GDP on RAB13 - Dictyostelium discoideum
[Reaction:R-CEL-8876615] RAB13 GEFs exchange GTP for GDP on RAB13 - Caenorhabditis elegans
[Reaction:R-DME-8876615] RAB13 GEFs exchange GTP for GDP on RAB13 - Drosophila melanogaster
[Reaction:R-XTR-8876615] RAB13 GEFs exchange GTP for GDP on RAB13 - Xenopus tropicalis
[Reaction:R-SSC-8876615] RAB13 GEFs exchange GTP for GDP on RAB13 - Sus scrofa
[Reaction:R-BTA-8876615] RAB13 GEFs exchange GTP for GDP on RAB13 - Bos taurus
[Reaction:R-CFA-8876615] RAB13 GEFs exchange GTP for GDP on RAB13 - Canis familiaris
[Reaction:R-RNO-8876615] RAB13 GEFs exchange GTP for GDP on RAB13 - Rattus norvegicus
[Reaction:R-MMU-8876615] RAB13 GEFs exchange GTP for GDP on RAB13 - Mus musculus
output
[DefinedSet:R-HSA-8875305] GDIs,CHMs [cytosol]
[SimpleEntity:R-ALL-29420] GDP [cytosol]
[Complex:R-HSA-8876599] GGC-RAB13:GTP [cell junction]
releaseDate
2016年09月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8933218] Marat, Andrea L, 2016年08月03日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8876615
summation
[Summation:8876614] RAB13 is involved in the trafficking of proteins in the bios...
Referrals
(hasEvent)
[Pathway:R-HSA-8876198] RAB GEFs exchange GTP for GDP on RABs
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