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Schema
>
Reaction
>
Entries
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)
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catalystActivity
[CatalystActivity:70584] glutamate dehydrogenase [NAD(P)+] activity of GLUD hexamer [mitochondrial matrix]
catalystActivityReference
[CatalystActivityReference:9643993] glutamate dehydrogenase [NAD(P)+] activity of GLUD hexamer [mitochondrial matrix] Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
category
transition
compartment
[Compartment:5460] mitochondrial matrix
crossReference
[DatabaseIdentifier:9925786] RHEA:15135
[DatabaseIdentifier:9925794] RHEA:11614
dbId
70589
displayName
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)
eventOf
[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism - Homo sapiens
followingEvent
[Reaction:R-HSA-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Homo sapiens
input
[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix]
[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
[DefinedSet:R-ALL-517496] NAD(P)H [mitochondrial matrix]
[SimpleEntity:R-ALL-113561] NH4+ [mitochondrial matrix]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:507955] Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
[LiteratureReference:199756] Partial amino acid sequence of the glutamate dehydrogenase of human liver and a revision of the sequence of the bovine enzyme
[LiteratureReference:507956] The structure of apo human glutamate dehydrogenase details subunit communication and allostery
maxDepth
1
modified
[InstanceEdit:10948619] Weiser, Joel, 2025年08月27日
name
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)
2-oxoglutarate + H(+) + NADH + NH4(+) => H2O + L-glutamate + NAD(+)
2-oxoglutarate + H(+) + NADPH + NH4(+) => H2O + L-glutamate + NADP(+)
negativePrecedingEvent
[NegativePrecedingEvent:9930393] Futile Cycle: GOT2 transaminates OA and L-Glu
[NegativePrecedingEvent:9930388] Futile Cycle: glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]
[NegativePrecedingEvent:9930382] Futile Cycle: glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)
[NegativePrecedingEvent:9930383] glutamine + H2O => glutamate + NH4+ (GLS)
orthologousEvent
[Reaction:R-DDI-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - Dictyostelium discoideum
[Reaction:R-CEL-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - Caenorhabditis elegans
[Reaction:R-DME-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - Drosophila melanogaster
[Reaction:R-GGA-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - Gallus gallus
[Reaction:R-XTR-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - Xenopus tropicalis
[Reaction:R-DRE-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - Danio rerio
[Reaction:R-SSC-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - Sus scrofa
[Reaction:R-BTA-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - Bos taurus
[Reaction:R-CFA-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - Canis familiaris
[Reaction:R-RNO-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - Rattus norvegicus
[Reaction:R-MMU-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - Mus musculus
output
[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
[SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix]
[DefinedSet:R-ALL-517495] NAD(P)+ [mitochondrial matrix]
regulatedBy
[PositiveRegulation:R-HSA-70590] Positive regulation by 'ADP [mitochondrial matrix]'
[NegativeRegulation:R-HSA-70591] Negative regulation by 'GTP [mitochondrial matrix]'
regulationReference
[RegulationReference:9641228] Positive regulation by 'ADP [mitochondrial matrix]' Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
[RegulationReference:9642935] Negative regulation by 'GTP [mitochondrial matrix]' Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations
releaseDate
2004年07月06日
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-70589
summation
[Summation:178464] Mitochondrial glutamate dehydrogenase 1 (GLUD1) catalyzes th...
updateTrackers
[UpdateTracker:9790718] Update Tracker - [Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] - v33:[addOutput]
[UpdateTracker:9928534] Update Tracker - [Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - v91:[modifyText]
[UpdateTracker:9790862] Update Tracker - [Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeRegulator, modifyText]
[UpdateTracker:9792272] Update Tracker - [Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] - v22:[addLiteratureReference]
Referrals
(updatedInstance)
[UpdateTracker:9790718] Update Tracker - [Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] - v33:[addOutput]
[UpdateTracker:9928534] Update Tracker - [Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - v91:[modifyText]
[UpdateTracker:9790862] Update Tracker - [Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeRegulator, modifyText]
[UpdateTracker:9792272] Update Tracker - [Reaction:70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1] - v22:[addLiteratureReference]
(hasEvent)
[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism
(precedingEvent)
[NegativePrecedingEvent:9930379] Futile Cycle: alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)
[NegativePrecedingEvent:9930385] Futile Cycle: alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)
[Reaction:R-HSA-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]
[NegativePrecedingEvent:9930397] Futile Cycle: alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)
(reverseReaction)
[Reaction:R-HSA-70600] glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)
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