Reactome Pathway Database

Schema > Reaction > Entries

alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) Show undefined attributes

catalystActivity

[CatalystActivity:10681630] glutamate dehydrogenase [NAD(P)+] activity of GLUD hexamer [mitochondrial matrix]

category transition

compartment

[Compartment:5460] mitochondrial matrix

created [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

dbId 10681632

displayName alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)

eventOf

[Pathway:R-GGA-8964539] Glutamate and glutamine metabolism - Gallus gallus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-GGA-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Gallus gallus

inferredFrom

[Reaction:R-HSA-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)
2-oxoglutarate + H(+) + NADH + NH4(+) => H2O + L-glutamate + NAD(+)
2-oxoglutarate + H(+) + NADPH + NH4(+) => H2O + L-glutamate + NADP(+)

output

regulatedBy

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49591] Gallus gallus

stId R-GGA-70589

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-GGA-8964539] Glutamate and glutamine metabolism

(precedingEvent)

[Reaction:R-GGA-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]

(inferredTo)

[Reaction:R-HSA-70589] alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)

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