Reactome Pathway Database

Schema > Reaction > Entries

glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] Show undefined attributes

catalystActivity

[CatalystActivity:10710354] delta1-pyrroline-5-carboxylate synthetase activity of P5CS dimers [mitochondrial inner membrane]

category transition

compartment

created [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

dbId 10710356

displayName glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]

eventOf

[Pathway:R-GGA-8964539] Glutamate and glutamine metabolism - Gallus gallus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-GGA-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Gallus gallus

inferredFrom

[Reaction:R-HSA-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS] - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]
ATP + H(+) + L-glutamate + NADPH => ADP + L-glutamate 5-semialdehyde + NADP(+) + phosphate

output

precedingEvent

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49591] Gallus gallus

stId R-GGA-508040

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-GGA-8964539] Glutamate and glutamine metabolism

(precedingEvent)

[Reaction:R-GGA-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]

(inferredTo)

[Reaction:R-HSA-508040] glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]

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