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Entries
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA
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authored
[InstanceEdit:73677] D'Eustachio, P, 2003年06月24日 00:00:00
catalystActivity
[CatalystActivity:70576] argininosuccinate synthase activity of ASS1 tetramer:NMRAL1 dimer:NADPH [cytosol]
catalystActivityReference
[CatalystActivityReference:9643595] argininosuccinate synthase activity of ASS1 tetramer:NMRAL1 dimer:NADPH [cytosol] Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene
category
transition
compartment
[Compartment:70101] cytosol
crossReference
[DatabaseIdentifier:12610661] Rhea:10933
dbId
70577
displayName
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA
edited
[InstanceEdit:73677] D'Eustachio, P, 2003年06月24日 00:00:00
eventOf
[Pathway:R-HSA-70635] Urea cycle - Homo sapiens
followingEvent
[Reaction:R-HSA-70573] argininosuccinate <=> fumarate + arginine - Homo sapiens
[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-29448] L-Asp [cytosol]
[SimpleEntity:R-ALL-29968] L-Cit [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:451985] Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene
[LiteratureReference:451992] Structure of human argininosuccinate synthetase
[LiteratureReference:74567] Isolation and characterization of argininosuccinate synthetase from human liver
[LiteratureReference:6810885] Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein
[LiteratureReference:6810872] An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA
ATP + aspartate + citrulline <=> argininosuccinate + AMP + pyrophosphate
orthologousEvent
[Reaction:R-GGA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Gallus gallus
[Reaction:R-SSC-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Sus scrofa
[Reaction:R-BTA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Bos taurus
[Reaction:R-CFA-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Canis familiaris
[Reaction:R-MMU-70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - Mus musculus
output
[SimpleEntity:R-ALL-76577] AMP [cytosol]
[SimpleEntity:R-ALL-34575] ARSUA [cytosol]
[SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent
[Reaction:R-HSA-70634] ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic) - Homo sapiens
[Reaction:R-HSA-70581] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] - Homo sapiens
releaseDate
2004年07月06日
reviewStatus
[ReviewStatus:9821382] five stars
revised
[InstanceEdit:452018] D'Eustachio, P, 2010年01月14日
[InstanceEdit:6810886] Jassal, Bijay, 2015年11月19日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-70577
summation
[Summation:178493] Cytosolic argininosuccinate synthase (ASS1 tetramer) catalyz...
updateTrackers
[UpdateTracker:9783430] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v56:[addLiteratureReference, modifyText]
[UpdateTracker:9789598] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v37:[modifyText]
[UpdateTracker:9791236] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v32:[add_removeLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9783430] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v56:[addLiteratureReference, modifyText]
[UpdateTracker:9789598] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v37:[modifyText]
[UpdateTracker:9791236] Update Tracker - [Reaction:70577] ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA - v32:[add_removeLiteratureReference, modifyText]
(hasEvent)
[Pathway:R-HSA-70635] Urea cycle
(precedingEvent)
[Reaction:R-HSA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate
[Reaction:R-HSA-70573] argininosuccinate <=> fumarate + arginine
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