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Formation of the cornified envelope
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authored
[InstanceEdit:8863769] Jupe, Steve, 2016年03月10日
created
[InstanceEdit:6809402] Jupe, Steve, 2015年11月11日
dbId
6809371
displayName
Formation of the cornified envelope
edited
[InstanceEdit:8934545] Jupe, Steve, 2016年08月10日
eventOf
[Pathway:R-HSA-6805567] Keratinization - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:396474] cornification
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-6810843] Envoplakin binds periplakin - Homo sapiens
[Reaction:R-HSA-6814187] EVL:PPL heterodimer binds the inner surface of the plasma membrane - Homo sapiens
[Reaction:R-HSA-6810899] TGM1 and involucrin bind the plasma membrane - Homo sapiens
[BlackBoxEvent:R-HSA-6810894] Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking - Homo sapiens
[Reaction:R-HSA-8849797] Membrane proteases cleave Profilaggrin producing Filaggrin - Homo sapiens
[Reaction:R-HSA-8934819] Cytoplasmic proteases cleave Profilaggrin producing Filaggrin - Homo sapiens
[Reaction:R-HSA-8942224] Filaggrin binds Keratin tonofilament:Desmosome - Homo sapiens
[Polymerisation:R-HSA-6810357] Fillagrin and keratin intermediate filaments polymerize forming a network - Homo sapiens
[BlackBoxEvent:R-HSA-6811539] Reinforcement of the Cornified Envelope - Homo sapiens
[Reaction:R-HSA-6810937] Lamellar bodies bind the early cornified envelope - Homo sapiens
[Reaction:R-HSA-6814734] CDSN binds the cornified envelope - Homo sapiens
[Reaction:R-HSA-6814298] Late envelope proteins bind cornified envelope:CDSN - Homo sapiens
[Reaction:R-HSA-6814387] CASP14 cleaves filaggrin - Homo sapiens
[BlackBoxEvent:R-HSA-6814764] Plasma membrane resorption - Homo sapiens
[Reaction:R-HSA-6814695] PERP binds desmosomes - Homo sapiens
[Reaction:R-HSA-6814374] Kazrin binds periplakin - Homo sapiens
[Reaction:R-HSA-8849826] ST14 hydrolyzes and activates KLK5 - Homo sapiens
[Reaction:R-HSA-8849646] SPINK5(490-624) binds KLK5 - Homo sapiens
[Reaction:R-HSA-8849638] Dissociation of the SPINK5:KLK5 complex at low pH - Homo sapiens
[Reaction:R-HSA-8849857] KLK5 cleaves and activates CELA2 - Homo sapiens
[Reaction:R-HSA-8850831] KLK5 cleaves and activates KLK8 - Homo sapiens
[Reaction:R-HSA-8850786] SPINK6 binds KLK12 - Homo sapiens
[Reaction:R-HSA-8850797] SPINK6 binds KLK13 - Homo sapiens
[Reaction:R-HSA-8850777] SPINK6 binds KLK14 - Homo sapiens
[Reaction:R-HSA-8850794] SPINK6 binds KLK5 - Homo sapiens
[Reaction:R-HSA-8850818] SPINK9 binds KLK5 - Homo sapiens
[Reaction:R-HSA-6789310] LIPs hydrolyse TG to DAG and RCOOH - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2017年06月22日
literatureReference
[LiteratureReference:6810349] The cornified envelope: a model of cell death in the skin
maxDepth
2
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Formation of the cornified envelope
orthologousEvent
[Pathway:R-MMU-6809371] Formation of the cornified envelope - Mus musculus
[Pathway:R-RNO-6809371] Formation of the cornified envelope - Rattus norvegicus
[Pathway:R-CFA-6809371] Formation of the cornified envelope - Canis familiaris
[Pathway:R-BTA-6809371] Formation of the cornified envelope - Bos taurus
[Pathway:R-SSC-6809371] Formation of the cornified envelope - Sus scrofa
[Pathway:R-DRE-6809371] Formation of the cornified envelope - Danio rerio
[Pathway:R-XTR-6809371] Formation of the cornified envelope - Xenopus tropicalis
[Pathway:R-GGA-6809371] Formation of the cornified envelope - Gallus gallus
[Pathway:R-CEL-6809371] Formation of the cornified envelope - Caenorhabditis elegans
[Pathway:R-DDI-6809371] Formation of the cornified envelope - Dictyostelium discoideum
[Pathway:R-SPO-6809371] Formation of the cornified envelope - Schizosaccharomyces pombe
[Pathway:R-SCE-6809371] Formation of the cornified envelope - Saccharomyces cerevisiae
[Pathway:R-PFA-6809371] Formation of the cornified envelope - Plasmodium falciparum
releaseDate
2016年09月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8934809] Blumenberg, Miroslav, 2016年08月12日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-6809371
summation
[Summation:6809396] As keratinocytes progress towards the upper epidermis, they ...
updateTrackers
[UpdateTracker:9782545] Update Tracker - [Pathway:6809371] Formation of the cornified envelope - v59:[addHasEvent, updateContainedRLE]
[UpdateTracker:9781057] Update Tracker - [Pathway:6809371] Formation of the cornified envelope - v61:[addHasEvent]
Referrals
(hasEvent)
[Pathway:R-HSA-6805567] Keratinization
(updatedInstance)
[UpdateTracker:9782545] Update Tracker - [Pathway:6809371] Formation of the cornified envelope - v59:[addHasEvent, updateContainedRLE]
[UpdateTracker:9781057] Update Tracker - [Pathway:6809371] Formation of the cornified envelope - v61:[addHasEvent]
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