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Dissociation of paradoxically activated RAS:BRAF complexes Show undefined attributes

authored

[InstanceEdit:6802811] Rothfels, Karen, 2015年08月10日

category dissociation

compartment

[Compartment:70101] cytosol

created [InstanceEdit:6803236] Rothfels, Karen, 2015年10月05日

crossReference

[DatabaseIdentifier:11944892] Mondo:0004992

dbId 6803234

disease

[Disease:1500689] cancer

displayName Dissociation of paradoxically activated RAS:BRAF complexes

edited

[InstanceEdit:6802811] Rothfels, Karen, 2015年08月10日

entityFunctionalStatus

[EntityFunctionalStatus:6803235] gain_of_function of RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]

eventOf

[Pathway:R-HSA-6802955] Paradoxical activation of RAF signaling by kinase inactive BRAF - Homo sapiens

input

[Complex:R-HSA-6802637] RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]

isChimeric false

isInDisease true

isInferred false

literatureReference

[LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Dissociation of paradoxically activated RAS:BRAF complexes

normalReaction [Reaction:R-HSA-5672980] Dissociation of RAS:RAF complex

output

releaseDate 2016年09月19日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:8933498] Stephens, Robert M, 2016年08月05日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-6803234

summation

[Summation:6803217] After phosphorylation by MAP2Ks, the scaffolded kinase compl...

Referrals

(hasEvent)

[Pathway:R-HSA-6802955] Paradoxical activation of RAF signaling by kinase inactive BRAF

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