Reactome Pathway Database

Schema > Complex > Entries

RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] Show undefined attributes

compartment

[Compartment:876] plasma membrane

consumedByEvent

[Reaction:R-HSA-6803234] Dissociation of paradoxically activated RAS:BRAF complexes - Homo sapiens

created [InstanceEdit:6802638] Rothfels, Karen, 2015年10月02日

dbId 6802637

displayName RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]

hasComponent

inDisease false

includedLocation

[Compartment:70101] cytosol

isChimeric false

maxDepth 11

modified [InstanceEdit:9037747] Rothfels, Karen, 2018年02月20日

name

RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins

producedByEvent

[Reaction:R-HSA-6802918] Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants - Homo sapiens

schemaClass Complex

species

[Species:48887] Homo sapiens

stId R-HSA-6802637

updateTrackers

Referrals

(updatedInstance)

(input)

[Reaction:R-HSA-6803234] Dissociation of paradoxically activated RAS:BRAF complexes

(diseaseEntity)

[EntityFunctionalStatus:6803235] gain_of_function of RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]

(output)

[Reaction:R-HSA-6802918] Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants

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