Reactome | RHO GTPases Activate Formins

authored

compartment

created [InstanceEdit:5663221] Orlic-Milacic, Marija, 2015年01月16日

dbId 5663220

displayName RHO GTPases Activate Formins

edited

[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015年02月02日

eventOf

[Pathway:R-HSA-195258] RHO GTPase Effectors - Homo sapiens

hasDiagram true

hasEHLD false

hasEvent

isInDisease false

isInferred false

literatureReference

[LiteratureReference:5665955] Formins as effector proteins of Rho GTPases
[LiteratureReference:5672364] The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition
[LiteratureReference:5663236] The regulation of mDia1 by autoinhibition and its release by Rho*GTP
[LiteratureReference:5672362] Structure of the autoinhibitory switch in formin mDia1
[LiteratureReference:5665948] Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture
[LiteratureReference:5665961] Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis
[LiteratureReference:5665957] Control of the assembly of ATP- and ADP-actin by formins and profilin
[LiteratureReference:5663237] FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages
[LiteratureReference:5665704] Dynamic remodeling of the actin cytoskeleton by FMNL1? is required for structural maintenance of the Golgi complex
[LiteratureReference:5665683] Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1
[LiteratureReference:5665745] Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC
[LiteratureReference:5665763] RhoA and RhoC have distinct roles in migration and invasion by acting through different targets
[LiteratureReference:5665974] Actin dynamics control SRF activity by regulation of its coactivator MAL
[LiteratureReference:5666075] RhoB regulates endosome transport by promoting actin assembly on endosomal membranes through Dia1
[LiteratureReference:5666061] RhoB and the mammalian Diaphanous-related formin mDia2 in endosome trafficking
[LiteratureReference:5666101] Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling
[LiteratureReference:5666086] RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase
[LiteratureReference:5666124] Cdc42 and mDia3 regulate microtubule attachment to kinetochores
[LiteratureReference:5666138] Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment
[LiteratureReference:351112] Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1
[LiteratureReference:5666152] A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility
[LiteratureReference:5672935] The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells

maxDepth 2

modified [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

name

RHO GTPases Activate Formins

orthologousEvent

releaseDate 2015年03月19日

reviewStatus [ReviewStatus:9821382] five stars

schemaClass Pathway

species

[Species:48887] Homo sapiens

stId R-HSA-5663220

summation

[Summation:5672351] Formins are a family of proteins with 15 members in mammals,...

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