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Entries
FMNL1 binds RAC1:GTP
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authored
[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014年10月24日
[InstanceEdit:5668821] Rivero Crespo, Francisco, 2014年12月26日
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:5663233] Orlic-Milacic, Marija, 2015年01月16日
dbId
5663232
displayName
FMNL1 binds RAC1:GTP
edited
[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015年02月02日
eventOf
[Pathway:R-HSA-5663220] RHO GTPases Activate Formins - Homo sapiens
followingEvent
[Reaction:R-HSA-5665659] RAC1:GTP:FMNL1 binds profilin:G-actin - Homo sapiens
inferredFrom
[Reaction:R-MMU-5663241] Fmnl1 binds Rac1:GTP - Mus musculus
input
[Complex:R-HSA-5665949] FMNL1 [cytosol]
[Complex:R-HSA-442641] RAC1:GTP [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
true
literatureReference
[LiteratureReference:5663237] FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages
[LiteratureReference:5663236] The regulation of mDia1 by autoinhibition and its release by Rho*GTP
[LiteratureReference:5663227] Structural and mechanistic insights into the interaction between Rho and mammalian Dia
[LiteratureReference:5665691] FMNL1 promotes proliferation and migration of leukemia cells
[LiteratureReference:5665716] Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing
[LiteratureReference:5665948] Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture
[LiteratureReference:5665955] Formins as effector proteins of Rho GTPases
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
FMNL1 binds RAC1:GTP
output
[Complex:R-HSA-5663231] RAC1:GTP:FMNL1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-8848618] Activation of RAC1 by the PXN:CRK complex - Homo sapiens
releaseDate
2015年03月19日
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5663232
summation
[Summation:5663228] FMNL1 (formin-like protein 1) binds the active, GTP-bound, f...
Referrals
(hasEvent)
[Pathway:R-HSA-5663220] RHO GTPases Activate Formins
(precedingEvent)
[Reaction:R-HSA-5665659] RAC1:GTP:FMNL1 binds profilin:G-actin
(inferredTo)
[Reaction:R-MMU-5663241] Fmnl1 binds Rac1:GTP
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