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Schema
>
Reaction
>
Entries
Anthrax lef cleaves target cell MAP2K1 (MEK1)
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authored
[InstanceEdit:5212697] D'Eustachio, Peter, 2013年12月13日
catalystActivity
[CatalystActivity:5211347] metallopeptidase activity of lef [cytosol]
catalystActivityReference
[CatalystActivityReference:9643065] metallopeptidase activity of LF [cytosol] Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:5211335] D'Eustachio, Peter, 2013年12月09日
crossReference
[DatabaseIdentifier:11944952] Mondo:0005119
dbId
5211340
disease
[Disease:5205706] anthrax disease
displayName
Anthrax lef cleaves target cell MAP2K1 (MEK1)
eventOf
[Pathway:R-HSA-5210891] Uptake and function of anthrax toxins - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-59502] MAP2K1 [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:5211331] Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
[LiteratureReference:5211333] Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity
[LiteratureReference:5211349] Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Anthrax lef cleaves target cell MAP2K1 (MEK1)
output
[EntityWithAccessionedSequence:R-HSA-5211342] MAP2K1(2-8) [cytosol]
[EntityWithAccessionedSequence:R-HSA-5211353] MAP2K1(9-393) [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-5210947] pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol) - Homo sapiens
[BlackBoxEvent:R-HSA-5210943] pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol) - Homo sapiens
relatedSpecies
[Species:5205709] Bacillus anthracis
releaseDate
2014年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5490366] Leppla, Stephen H, 2014年05月19日
[InstanceEdit:5576992] Liu, Shihui, 2014年05月28日
[InstanceEdit:5576994] Moayeri, Mahtab, 2014年05月28日
[InstanceEdit:5567362] Turk, Benjamin E, 2014年05月23日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5211340
summation
[Summation:5211355] lef (Anthrax LF, lethal factor), a zinc metalloprotease (Kli...
updateTrackers
[UpdateTracker:9776580] Update Tracker - [Reaction:5211340] Anthrax lef cleaves target cell MAP2K1 (MEK1) - v75:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9776580] Update Tracker - [Reaction:5211340] Anthrax lef cleaves target cell MAP2K1 (MEK1) - v75:[modifyText]
(hasEvent)
[Pathway:R-HSA-5210891] Uptake and function of anthrax toxins
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