dbId
5211355
displayName
lef (Anthrax LF, lethal factor), a zinc metalloprotease (Kli...
schemaClass
Summation
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lef (Anthrax LF, lethal factor), a zinc metalloprotease (Klimpel et al, 1994) in the target cell cytosol, cleaves MAP2K1 (MEK1, mitogen activated protein kinase kinase 1) at the N-terminus. While the kinase domain of MAP2K1 is unaffected, an aminoterminal docking domain is disrupted by the cleavage and the protein fails to interact normally with substrates (Duesbery et al. 1998; Vitale et al. 1998).