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Entries
Detoxification of Reactive Oxygen Species
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authored
[InstanceEdit:3299684] May, B, 2013年04月20日
compartment
[Compartment:70101] cytosol
[Compartment:17957] endoplasmic reticulum lumen
[Compartment:984] extracellular region
[Compartment:70616] mitochondrial inner membrane
[Compartment:17927] mitochondrial intermembrane space
[Compartment:5460] mitochondrial matrix
[Compartment:17951] peroxisomal matrix
created
[InstanceEdit:3299677] May, B, 2013年04月20日
crossReference
[DatabaseIdentifier:12758102] BioModels Database:BIOMD0000000575
dbId
3299685
deleted
[Deleted:8953901] Deletion of instance: 2262748
displayName
Detoxification of Reactive Oxygen Species
doi
10.3180/REACT_172715.1
edited
[InstanceEdit:3299684] May, B, 2013年04月20日
eventOf
[Pathway:R-HSA-9711123] Cellular response to chemical stress - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:376615] cellular response to oxidative stress
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-3697860] SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ - Homo sapiens
[Reaction:R-HSA-8951723] 2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates - Homo sapiens
[Reaction:R-HSA-3299753] CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 - Homo sapiens
[Reaction:R-HSA-3780958] SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) - Homo sapiens
[Reaction:R-HSA-3780979] CCS transfers Cu to SOD1 (mitochondrial) - Homo sapiens
[BlackBoxEvent:R-HSA-3697838] ATP7A transfers Cu from ATOX1 to SOD3 - Homo sapiens
[BlackBoxEvent:R-HSA-4837364] Secretion of SOD3 - Homo sapiens
[Reaction:R-HSA-6807557] NOX4, NOX5 reduce O2 to O2.- - Homo sapiens
[Reaction:R-HSA-3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) - Homo sapiens
[Reaction:R-HSA-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Homo sapiens
[Reaction:R-HSA-3299680] SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix) - Homo sapiens
[Reaction:R-HSA-3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) - Homo sapiens
[Reaction:R-HSA-3779381] H2O2 diffuses from the mitochondrial matrix to the cytosol - Homo sapiens
[Reaction:R-HSA-76031] 2 H2O2 => O2 + 2 H2O - Homo sapiens
[Reaction:R-HSA-3323013] GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Homo sapiens
[Reaction:R-HSA-3323079] GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Homo sapiens
[Reaction:R-HSA-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O - Homo sapiens
[Reaction:R-HSA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Homo sapiens
[Reaction:R-HSA-3341277] GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Homo sapiens
[Reaction:R-HSA-3341397] GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Homo sapiens
[Reaction:R-HSA-3322995] PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O - Homo sapiens
[Reaction:R-HSA-3323050] TXNRD2 catalyzes the reduction of TXN2 by NADPH - Homo sapiens
[Reaction:R-HSA-3341294] Superoxide reduces cytochrome c - Homo sapiens
[Reaction:R-HSA-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Homo sapiens
[Reaction:R-HSA-73646] thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ - Homo sapiens
[Reaction:R-HSA-6799695] GPX5,6 reduce H2O2 to H2O - Homo sapiens
[Reaction:R-HSA-3341296] GPX7,8 catalyze peroxidation of P4HB (PDI) - Homo sapiens
[Reaction:R-HSA-3343700] PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Homo sapiens
[Reaction:R-HSA-3697882] PRDX5 reduces peroxynitrite to nitrite using TXN - Homo sapiens
[Reaction:R-HSA-3697894] PRDX5 reduces peroxynitrite to nitrite using TXN2 - Homo sapiens
[Reaction:R-HSA-5696197] NUDT2 hydrolyses GP4G to GTP, GMP - Homo sapiens
[Reaction:R-HSA-1222376] NOX2 generates superoxide from oxygen - Homo sapiens
[Reaction:R-HSA-1222407] Superoxide and nitric oxide react to peroxynitrite - Homo sapiens
[Reaction:R-HSA-3697855] Superoxide and nitric oxide react to form peroxynitrite in mitochondria - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2021年06月14日
literatureReference
[LiteratureReference:3299790] Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide
[LiteratureReference:3299816] Superoxide dismutases: role in redox signaling, vascular function, and diseases
[LiteratureReference:3299777] Oxidative stress and antioxidant defense
[LiteratureReference:3299811] Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
[LiteratureReference:3779356] Hydrogen peroxide as a signaling molecule
[LiteratureReference:3782519] Mathematical and computational models of oxidative and nitrosative stress
[LiteratureReference:3782523] The sites and topology of mitochondrial superoxide production
[LiteratureReference:3782521] How mitochondria produce reactive oxygen species
[LiteratureReference:4837345] Computational insights into the role of glutathione in oxidative stress
maxDepth
2
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Detoxification of Reactive Oxygen Species
orthologousEvent
[Pathway:R-DRE-3299685] Detoxification of Reactive Oxygen Species - Danio rerio
[Pathway:R-PFA-3299685] Detoxification of Reactive Oxygen Species - Plasmodium falciparum
[Pathway:R-SCE-3299685] Detoxification of Reactive Oxygen Species - Saccharomyces cerevisiae
[Pathway:R-SPO-3299685] Detoxification of Reactive Oxygen Species - Schizosaccharomyces pombe
[Pathway:R-DDI-3299685] Detoxification of Reactive Oxygen Species - Dictyostelium discoideum
[Pathway:R-CEL-3299685] Detoxification of Reactive Oxygen Species - Caenorhabditis elegans
[Pathway:R-DME-3299685] Detoxification of Reactive Oxygen Species - Drosophila melanogaster
[Pathway:R-GGA-3299685] Detoxification of Reactive Oxygen Species - Gallus gallus
[Pathway:R-XTR-3299685] Detoxification of Reactive Oxygen Species - Xenopus tropicalis
[Pathway:R-SSC-3299685] Detoxification of Reactive Oxygen Species - Sus scrofa
[Pathway:R-BTA-3299685] Detoxification of Reactive Oxygen Species - Bos taurus
[Pathway:R-CFA-3299685] Detoxification of Reactive Oxygen Species - Canis familiaris
[Pathway:R-RNO-3299685] Detoxification of Reactive Oxygen Species - Rattus norvegicus
[Pathway:R-MMU-3299685] Detoxification of Reactive Oxygen Species - Mus musculus
releaseDate
2013年12月04日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:4837339] Kavdia, Mahendra, 2013年11月01日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-3299685
summation
[Summation:3299810] Reactive oxygen species such as superoxide (O2.-), peroxides...
updateTrackers
[UpdateTracker:9782313] Update Tracker - [Pathway:3299685] Detoxification of Reactive Oxygen Species - v59:[addHasEvent]
[UpdateTracker:9781936] Update Tracker - [Pathway:3299685] Detoxification of Reactive Oxygen Species - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9784183] Update Tracker - [Pathway:3299685] Detoxification of Reactive Oxygen Species - v54:[addHasEvent]
[UpdateTracker:9786166] Update Tracker - [Pathway:3299685] Detoxification of Reactive Oxygen Species - v50:[updateContainedRLE]
[UpdateTracker:9776257] Update Tracker - [Pathway:3299685] Detoxification of Reactive Oxygen Species - v77:[updateContainedRLE]
[UpdateTracker:9783445] Update Tracker - [Pathway:3299685] Detoxification of Reactive Oxygen Species - v56:[addHasEvent, updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-9711123] Cellular response to chemical stress
(hasEncapsulatedEvent)
[Pathway:R-HSA-9818027] NFE2L2 regulating anti-oxidant/detoxification enzymes
[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
(replacementInstances)
[Deleted:8953901] Deletion of instance: 2262748
(updatedInstance)
[UpdateTracker:9782313] Update Tracker - [Pathway:3299685] Detoxification of Reactive Oxygen Species - v59:[addHasEvent]
[UpdateTracker:9781936] Update Tracker - [Pathway:3299685] Detoxification of Reactive Oxygen Species - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9784183] Update Tracker - [Pathway:3299685] Detoxification of Reactive Oxygen Species - v54:[addHasEvent]
[UpdateTracker:9786166] Update Tracker - [Pathway:3299685] Detoxification of Reactive Oxygen Species - v50:[updateContainedRLE]
[UpdateTracker:9776257] Update Tracker - [Pathway:3299685] Detoxification of Reactive Oxygen Species - v77:[updateContainedRLE]
[UpdateTracker:9783445] Update Tracker - [Pathway:3299685] Detoxification of Reactive Oxygen Species - v56:[addHasEvent, updateContainedRLE]
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