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Schema
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Reaction
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Entries
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+
Show undefined attributes
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authored
[InstanceEdit:73446] Jassal, B, 2003年06月17日 09:00:25
catalystActivity
[CatalystActivity:73533] thioredoxin-disulfide reductase (NADPH) activity of TNXRD1:FAD dimer [cytosol]
catalystActivityReference
[CatalystActivityReference:9643312] thioredoxin-disulfide reductase activity of TNXRD1:FAD dimer [cytosol] Truncated mutants of human thioredoxin reductase 1 do not exhibit glutathione reductase activity
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:73446] Jassal, B, 2003年06月17日 09:00:25
dbId
73646
deleted
[Deleted:8866417] Deletion of instance: 111806
displayName
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+
edited
[InstanceEdit:73446] Jassal, B, 2003年06月17日 09:00:25
[InstanceEdit:504064] D'Eustachio, P, 2010年02月05日
eventOf
[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens
[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates - Homo sapiens
[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species - Homo sapiens
followingEvent
[Reaction:R-HSA-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Homo sapiens
[Reaction:R-HSA-111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Homo sapiens
[Reaction:R-HSA-3697882] PRDX5 reduces peroxynitrite to nitrite using TXN - Homo sapiens
[Reaction:R-HSA-5631885] PRDX1 overoxidizes - Homo sapiens
[Reaction:R-HSA-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-73668] 2xHC-TXN [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:200264] Truncated mutants of human thioredoxin reductase 1 do not exhibit glutathione reductase activity
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+
regeneration of active (reduced) Thioredoxin
orthologousEvent
[Reaction:R-PFA-73646] thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ - Plasmodium falciparum
[Reaction:R-CEL-73646] thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ - Caenorhabditis elegans
[Reaction:R-GGA-73646] thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ - Gallus gallus
[Reaction:R-BTA-73646] thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ - Bos taurus
[Reaction:R-RNO-73646] thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ - Rattus norvegicus
[Reaction:R-MMU-73646] thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ - Mus musculus
output
[SimpleEntity:R-ALL-29366] NADP+ [cytosol]
[EntityWithAccessionedSequence:R-HSA-66000] TXN [cytosol]
releaseDate
2004年07月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855680] Inga, Alberto, 2016年02月04日
[InstanceEdit:8855677] Zaccara, Sara, 2016年02月04日
revised
[InstanceEdit:504064] D'Eustachio, P, 2010年02月05日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-73646
summation
[Summation:499946] Cytosolic thioredoxin reductase catalyzes the reaction of th...
updateTrackers
[UpdateTracker:9792388] Update Tracker - [Reaction:73646] thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ - v22:[addLiteratureReference]
[UpdateTracker:9791229] Update Tracker - [Reaction:73646] thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ - v32:[add_removeSummation]
Referrals
(updatedInstance)
[UpdateTracker:9792388] Update Tracker - [Reaction:73646] thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ - v22:[addLiteratureReference]
[UpdateTracker:9791229] Update Tracker - [Reaction:73646] thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ - v32:[add_removeSummation]
(replacementInstances)
[Deleted:8866417] Deletion of instance: 111806
(hasEvent)
[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes
[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates
[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species
(precedingEvent)
[Reaction:R-HSA-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)
[Reaction:R-HSA-111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)
[Reaction:R-HSA-3697882] PRDX5 reduces peroxynitrite to nitrite using TXN
[Reaction:R-HSA-5631885] PRDX1 overoxidizes
[Reaction:R-HSA-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O
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