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Schema
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Pathway
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Entries
Phase I - Functionalization of compounds
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authored
[InstanceEdit:350358] Jassal, Bijay, 2008年05月19日
compartment
[Compartment:70101] cytosol
[Compartment:70616] mitochondrial inner membrane
[Compartment:17906] mitochondrial outer membrane
[Compartment:5460] mitochondrial matrix
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:17957] endoplasmic reticulum lumen
created
[InstanceEdit:211969] Jassal, B, 2008年02月08日 15:33:52
dbId
211945
diseasePathways
[Pathway:R-HSA-5579000] Defective CYP1B1 causes Glaucoma - Homo sapiens
[Pathway:R-HSA-5579004] Defective CYP26C1 causes FFDD4 - Homo sapiens
[Pathway:R-HSA-5579005] Defective CYP4F22 causes ARCI5 - Homo sapiens
[Pathway:R-HSA-5579019] Defective FMO3 causes TMAU - Homo sapiens
[Pathway:R-HSA-5579017] Defective CYP11B1 causes AH4 - Homo sapiens
[Pathway:R-HSA-5579021] Defective CYP21A2 causes AH3 - Homo sapiens
[Pathway:R-HSA-5579010] Defective CYP24A1 causes HCAI - Homo sapiens
[Pathway:R-HSA-5579011] Defective CYP2U1 causes SPG56 - Homo sapiens
[Pathway:R-HSA-5579009] Defective CYP11B2 causes CMO-1 deficiency - Homo sapiens
[Pathway:R-HSA-5579015] Defective CYP26B1 causes RHFCA - Homo sapiens
[Pathway:R-HSA-5579012] Defective MAOA causes BRUNS - Homo sapiens
[Pathway:R-HSA-5579013] Defective CYP7B1 causes SPG5A and CBAS3 - Homo sapiens
[Pathway:R-HSA-5579032] Defective TBXAS1 causes GHDD - Homo sapiens
[Pathway:R-HSA-5579026] Defective CYP11A1 causes AICSR - Homo sapiens
[Pathway:R-HSA-5579030] Defective CYP19A1 causes AEXS - Homo sapiens
displayName
Phase I - Functionalization of compounds
edited
[InstanceEdit:350358] Jassal, Bijay, 2008年05月19日
eventOf
[Pathway:R-HSA-211859] Biological oxidations - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:8764] xenobiotic metabolic process
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-211897] Cytochrome P450 - arranged by substrate type - Homo sapiens
[Pathway:R-HSA-217271] FMO oxidises nucleophiles - Homo sapiens
[Pathway:R-HSA-140180] COX reactions - Homo sapiens
[Pathway:R-HSA-140179] Amine Oxidase reactions - Homo sapiens
[Pathway:R-HSA-71384] Ethanol oxidation - Homo sapiens
[Reaction:R-HSA-5692283] ALD3A1 oxidises 4HPCP to CXPA - Homo sapiens
[Reaction:R-HSA-5693691] CES1 trimer.CES2 hydrolyse COCN to BEG - Homo sapiens
[Reaction:R-HSA-5694077] EPHX1 hydrates BaP4,5O to BaP4,5-DHD - Homo sapiens
[Reaction:R-HSA-5696131] AOC1 deaminates Hist - Homo sapiens
[Reaction:R-HSA-5696146] AOC2 deaminates TYR - Homo sapiens
[Reaction:R-HSA-5696183] AOC3 deaminates BZAM - Homo sapiens
[Reaction:R-HSA-5689000] AADAC deacetylates PHEN - Homo sapiens
[Reaction:R-HSA-6784959] BPHL hydrolyses VACV to ACV - Homo sapiens
[Reaction:R-HSA-6786190] CMBL hydrolyses OM to OLMS - Homo sapiens
[Reaction:R-HSA-8936442] MARC1,MARC2 reduce N-hydroxylated compounds - Homo sapiens
[Reaction:R-HSA-8936519] NQO2:FAD dimer reduces quinones to hydroquinones - Homo sapiens
[Reaction:R-HSA-8937419] CBR3 reduces DOX to DOXOL - Homo sapiens
[Reaction:R-HSA-8937442] CES3 hydrolyses CHEST to CHOL and LCFA(-) - Homo sapiens
[Pathway:R-HSA-8937144] Aryl hydrocarbon receptor signalling - Homo sapiens
[Reaction:R-HSA-9678766] CYP3A4 binds CYP3A4 inhibitors - Homo sapiens
[Reaction:R-HSA-9680865] CYP3A4, CYP2B6 bind ritonavir - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2023年09月13日
literatureReference
[LiteratureReference:266270] Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics
[LiteratureReference:266174] Cytochrome P450s and other enzymes in drug metabolism and toxicity
[LiteratureReference:266241] The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans
maxDepth
5
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Phase I - Functionalization of compounds
orthologousEvent
[Pathway:R-MMU-211945] Phase I - Functionalization of compounds - Mus musculus
[Pathway:R-RNO-211945] Phase I - Functionalization of compounds - Rattus norvegicus
[Pathway:R-CFA-211945] Phase I - Functionalization of compounds - Canis familiaris
[Pathway:R-BTA-211945] Phase I - Functionalization of compounds - Bos taurus
[Pathway:R-SSC-211945] Phase I - Functionalization of compounds - Sus scrofa
[Pathway:R-DRE-211945] Phase I - Functionalization of compounds - Danio rerio
[Pathway:R-XTR-211945] Phase I - Functionalization of compounds - Xenopus tropicalis
[Pathway:R-GGA-211945] Phase I - Functionalization of compounds - Gallus gallus
[Pathway:R-DME-211945] Phase I - Functionalization of compounds - Drosophila melanogaster
[Pathway:R-CEL-211945] Phase I - Functionalization of compounds - Caenorhabditis elegans
[Pathway:R-DDI-211945] Phase I - Functionalization of compounds - Dictyostelium discoideum
[Pathway:R-SPO-211945] Phase I - Functionalization of compounds - Schizosaccharomyces pombe
[Pathway:R-SCE-211945] Phase I - Functionalization of compounds - Saccharomyces cerevisiae
[Pathway:R-PFA-211945] Phase I - Functionalization of compounds - Plasmodium falciparum
releaseDate
2008年06月30日
releaseStatus
UPDATED
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:351775] D'Eustachio, P, 2008年05月28日 08:30:54
revised
[InstanceEdit:350358] Jassal, Bijay, 2008年05月19日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-211945
summation
[Summation:76366] Phase 1 of metabolism is concerned with
functionalizat...
updateTrackers
[UpdateTracker:9774727] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v81:[addHasEvent, updateContainedPathway]
[UpdateTracker:9781966] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v60:[updateIndirectRLE]
[UpdateTracker:9788331] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9778732] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v67:[updateContainedPathway, updateContainedRLE]
[UpdateTracker:9783567] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v56:[updateContainedPathway]
[UpdateTracker:9791653] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v28:[updateIndirectRLE]
[UpdateTracker:9784490] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v54:[addHasEvent, updateContainedPathway]
[UpdateTracker:9782426] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v59:[addHasEvent, updateContainedRLE]
[UpdateTracker:9783996] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v55:[addHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9785858] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v51:[updateContainedPathway]
[UpdateTracker:9791021] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v32:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9786590] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v49:[updateContainedPathway]
[UpdateTracker:9789875] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v37:[updateIndirectRLE]
[UpdateTracker:9842219] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v86:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9790558] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v33:[updateContainedPathway]
[UpdateTracker:9788527] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v41:[updateIndirectRLE]
[UpdateTracker:9786245] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v50:[updateContainedPathway, updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-211859] Biological oxidations
(normalPathway)
[Pathway:R-HSA-5579000] Defective CYP1B1 causes Glaucoma
[Pathway:R-HSA-5579004] Defective CYP26C1 causes FFDD4
[Pathway:R-HSA-5579005] Defective CYP4F22 causes ARCI5
[Pathway:R-HSA-5579019] Defective FMO3 causes TMAU
[Pathway:R-HSA-5579017] Defective CYP11B1 causes AH4
[Pathway:R-HSA-5579021] Defective CYP21A2 causes AH3
[Pathway:R-HSA-5579010] Defective CYP24A1 causes HCAI
[Pathway:R-HSA-5579011] Defective CYP2U1 causes SPG56
[Pathway:R-HSA-5579009] Defective CYP11B2 causes CMO-1 deficiency
[Pathway:R-HSA-5579015] Defective CYP26B1 causes RHFCA
[Pathway:R-HSA-5579012] Defective MAOA causes BRUNS
[Pathway:R-HSA-5579013] Defective CYP7B1 causes SPG5A and CBAS3
[Pathway:R-HSA-5579032] Defective TBXAS1 causes GHDD
[Pathway:R-HSA-5579026] Defective CYP11A1 causes AICSR
[Pathway:R-HSA-5579030] Defective CYP19A1 causes AEXS
(updatedInstance)
[UpdateTracker:9774727] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v81:[addHasEvent, updateContainedPathway]
[UpdateTracker:9781966] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v60:[updateIndirectRLE]
[UpdateTracker:9788331] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9778732] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v67:[updateContainedPathway, updateContainedRLE]
[UpdateTracker:9783567] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v56:[updateContainedPathway]
[UpdateTracker:9791653] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v28:[updateIndirectRLE]
[UpdateTracker:9784490] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v54:[addHasEvent, updateContainedPathway]
[UpdateTracker:9782426] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v59:[addHasEvent, updateContainedRLE]
[UpdateTracker:9783996] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v55:[addHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9785858] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v51:[updateContainedPathway]
[UpdateTracker:9791021] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v32:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9786590] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v49:[updateContainedPathway]
[UpdateTracker:9789875] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v37:[updateIndirectRLE]
[UpdateTracker:9842219] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v86:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9790558] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v33:[updateContainedPathway]
[UpdateTracker:9788527] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v41:[updateIndirectRLE]
[UpdateTracker:9786245] Update Tracker - [Pathway:211945] Phase I - Functionalization of compounds - v50:[updateContainedPathway, updateIndirectRLE]
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