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CYP3A4 binds CYP3A4 inhibitors Show undefined attributes

authored

[InstanceEdit:9678968] Jassal, Bijay, 2020年03月23日

category binding

compartment

created [InstanceEdit:9678968] Jassal, Bijay, 2020年03月23日

dbId 9678766

definition Inhibition

displayName CYP3A4 binds CYP3A4 inhibitors

edited

eventOf

[Pathway:R-HSA-211945] Phase I - Functionalization of compounds - Homo sapiens

input

isInDisease false

isInferred false

literatureReference

[LiteratureReference:9678732] Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions
[LiteratureReference:9678622] Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug-drug interaction studies
[LiteratureReference:9678942] Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes
[LiteratureReference:9681265] Cobicistat, a pharmacoenhancer for HIV treatments
[LiteratureReference:9681246] Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer

maxDepth 1

modified [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

name

CYP3A4 binds CYP3A4 inhibitors

orthologousEvent

output

[Complex:R-HSA-9679000] CYP3A4:CYP3A4 inhibitors [endoplasmic reticulum membrane]

releaseDate 2022年06月09日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9767610] Huddart, Rachel, 2022年03月01日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9678766

summation

[Summation:9681849] These compounds are inhibitors of cytochrome P450 3A enzymes...

Referrals

(hasEvent)

[Pathway:R-HSA-211945] Phase I - Functionalization of compounds

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