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CYP3A4, CYP2B6 bind ritonavir Show undefined attributes

authored

[InstanceEdit:9680828] Jassal, Bijay, 2020年03月30日

category binding

compartment

created [InstanceEdit:9680828] Jassal, Bijay, 2020年03月30日

dbId 9680865

definition Inhibition

displayName CYP3A4, CYP2B6 bind ritonavir

edited

eventOf

[Pathway:R-HSA-211945] Phase I - Functionalization of compounds - Homo sapiens

input

isInDisease false

isInferred false

literatureReference

[LiteratureReference:9678903] Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir
[LiteratureReference:9678622] Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug-drug interaction studies
[LiteratureReference:9680827] Mechanism-based inactivation of CYP3A by HIV protease inhibitors
[LiteratureReference:9680876] Compounds with therapeutic potential against novel respiratory 2019 coronavirus
[LiteratureReference:9680879] Unrevealing sequence and structural features of novel coronavirus using in silico approaches: The main protease as molecular target
[LiteratureReference:9680903] A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19
[LiteratureReference:9680871] Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study
[LiteratureReference:9680873] Coronavirus puts drug repurposing on the fast track

maxDepth 1

modified [InstanceEdit:10948619] Weiser, Joel, 2025年08月27日

name

CYP3A4, CYP2B6 bind ritonavir

orthologousEvent

output

[Complex:R-HSA-9680864] CYP3A4,CYP2B6:ritinovir [endoplasmic reticulum membrane]

releaseDate 2022年06月09日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9767610] Huddart, Rachel, 2022年03月01日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9680865

summation

[Summation:9680925] Ritonavir binds and inhibits Cytochrome P450 3A4 (CYP3A4), t...

Referrals

(hasEvent)

[Pathway:R-HSA-211945] Phase I - Functionalization of compounds

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