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Schema
>
Pathway
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Entries
Signaling by BMP
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authored
[InstanceEdit:202631] Huminiecki, L, Moustakas, A, 2007年11月07日 10:22:00
created
[InstanceEdit:201460] Jassal, B, 2007年08月13日 08:42:05
dbId
201451
displayName
Signaling by BMP
doi
10.3180/REACT_12034.1
eventOf
[Pathway:R-HSA-9006936] Signaling by TGFB family members - Homo sapiens
figure
[Figure:2127639] /figures/Pathway_Illustrations/BMP_72_oicr.png
goBiologicalProcess
[GO_BiologicalProcess:23761] BMP signaling pathway
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-201810] The ligand trap binds the ligand BMP2, blocking BMP signalling - Homo sapiens
[Reaction:R-HSA-202604] Formation of a heteromeric BMP receptor complex - Homo sapiens
[Reaction:R-HSA-201457] BMP2 binds to the receptor complex - Homo sapiens
[Reaction:R-HSA-201443] Type II receptor phosphorylates type I receptor - Homo sapiens
[Reaction:R-HSA-201648] An anchoring protein, Endofin, recruits R-Smad1/5/8 - Homo sapiens
[BlackBoxEvent:R-HSA-201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - Homo sapiens
[Reaction:R-HSA-201821] I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated - Homo sapiens
[Reaction:R-HSA-201476] Activated type I receptor phosphorylates R-Smad1/5/8 directly - Homo sapiens
[Reaction:R-HSA-201453] Phospho-R-Smad1/5/8 dissociates from the receptor complex - Homo sapiens
[Reaction:R-HSA-202626] I-Smad competes with Co-Smad for R-Smad1/5/8 - Homo sapiens
[Reaction:R-HSA-201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - Homo sapiens
[Reaction:R-HSA-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Homo sapiens
[BlackBoxEvent:R-HSA-201425] Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling - Homo sapiens
[Reaction:R-HSA-201423] SKI complexes with the Smad complex, suppressing BMP2 signalling - Homo sapiens
[Reaction:R-HSA-201475] I-Smad competes with R-Smad1/5/8 for type I receptor - Homo sapiens
[Reaction:R-HSA-8858346] AMHR2 binds AMH - Homo sapiens
[Reaction:R-HSA-8858369] ACVRL1 binds BMP9,BMP10 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2023年09月13日
literatureReference
[LiteratureReference:1497901] Bone morphogenetic protein receptors and signal transduction
[LiteratureReference:8984599] Bone Morphogenetic Proteins in Vascular Homeostasis and Disease
maxDepth
2
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Signaling by BMP
orthologousEvent
[Pathway:R-MMU-201451] Signaling by BMP - Mus musculus
[Pathway:R-RNO-201451] Signaling by BMP - Rattus norvegicus
[Pathway:R-CFA-201451] Signaling by BMP - Canis familiaris
[Pathway:R-BTA-201451] Signaling by BMP - Bos taurus
[Pathway:R-SSC-201451] Signaling by BMP - Sus scrofa
[Pathway:R-DRE-201451] Signaling by BMP - Danio rerio
[Pathway:R-XTR-201451] Signaling by BMP - Xenopus tropicalis
[Pathway:R-GGA-201451] Signaling by BMP - Gallus gallus
[Pathway:R-DME-201451] Signaling by BMP - Drosophila melanogaster
[Pathway:R-CEL-201451] Signaling by BMP - Caenorhabditis elegans
releaseDate
2007年12月11日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:203122] Heldin, CH, 2007年11月12日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-201451
summation
[Summation:201429] Bone morphogenetic proteins (BMPs) have many biological acti...
updateTrackers
[UpdateTracker:9783460] Update Tracker - [Pathway:201451] Signaling by BMP - v56:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9781283] Update Tracker - [Pathway:201451] Signaling by BMP - v61:[addLiteratureReference, updateContainedRLE]
[UpdateTracker:9842247] Update Tracker - [Pathway:201451] Signaling by BMP - v86:[updateContainedRLE]
[UpdateTracker:9781529] Update Tracker - [Pathway:201451] Signaling by BMP - v60:[addHasEvent]
[UpdateTracker:9777957] Update Tracker - [Pathway:201451] Signaling by BMP - v68:[updateContainedRLE]
[UpdateTracker:9777153] Update Tracker - [Pathway:201451] Signaling by BMP - v72:[updateContainedRLE]
[UpdateTracker:9787177] Update Tracker - [Pathway:201451] Signaling by BMP - v46:[updateContainedRLE]
[UpdateTracker:9789066] Update Tracker - [Pathway:201451] Signaling by BMP - v39:[addHasEvent, updateContainedRLE]
[UpdateTracker:9788707] Update Tracker - [Pathway:201451] Signaling by BMP - v41:[updateContainedRLE]
[UpdateTracker:9775665] Update Tracker - [Pathway:201451] Signaling by BMP - v78:[updateContainedRLE]
[UpdateTracker:9787989] Update Tracker - [Pathway:201451] Signaling by BMP - v44:[updateContainedRLE]
[UpdateTracker:9789482] Update Tracker - [Pathway:201451] Signaling by BMP - v38:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-9006936] Signaling by TGFB family members
(hasEncapsulatedEvent)
[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2
[Pathway:R-HSA-9839373] Signaling by TGFBR3
(updatedInstance)
[UpdateTracker:9783460] Update Tracker - [Pathway:201451] Signaling by BMP - v56:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9781283] Update Tracker - [Pathway:201451] Signaling by BMP - v61:[addLiteratureReference, updateContainedRLE]
[UpdateTracker:9842247] Update Tracker - [Pathway:201451] Signaling by BMP - v86:[updateContainedRLE]
[UpdateTracker:9781529] Update Tracker - [Pathway:201451] Signaling by BMP - v60:[addHasEvent]
[UpdateTracker:9777957] Update Tracker - [Pathway:201451] Signaling by BMP - v68:[updateContainedRLE]
[UpdateTracker:9777153] Update Tracker - [Pathway:201451] Signaling by BMP - v72:[updateContainedRLE]
[UpdateTracker:9787177] Update Tracker - [Pathway:201451] Signaling by BMP - v46:[updateContainedRLE]
[UpdateTracker:9789066] Update Tracker - [Pathway:201451] Signaling by BMP - v39:[addHasEvent, updateContainedRLE]
[UpdateTracker:9788707] Update Tracker - [Pathway:201451] Signaling by BMP - v41:[updateContainedRLE]
[UpdateTracker:9775665] Update Tracker - [Pathway:201451] Signaling by BMP - v78:[updateContainedRLE]
[UpdateTracker:9787989] Update Tracker - [Pathway:201451] Signaling by BMP - v44:[updateContainedRLE]
[UpdateTracker:9789482] Update Tracker - [Pathway:201451] Signaling by BMP - v38:[updateContainedRLE]
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