Reactome Pathway Database

Schema > BlackBoxEvent > Entries

Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling Show undefined attributes

authored

[InstanceEdit:202631] Huminiecki, L, Moustakas, A, 2007年11月07日 10:22:00

catalystActivity

[CatalystActivity:173531] ubiquitin-protein transferase activity of Nuclear ubiquitin ligase [nucleoplasm]

category omitted

compartment

[Compartment:7660] nucleoplasm

created [InstanceEdit:201460] Jassal, B, 2007年08月13日 08:42:05

dbId 201425

displayName Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling

eventOf

[Pathway:R-HSA-201451] Signaling by BMP - Homo sapiens

goBiologicalProcess [GO_BiologicalProcess:23767] negative regulation of BMP signaling pathway

input

[Complex:R-HSA-201450] p-2S-SMAD1/5/8:SMAD4 [nucleoplasm]

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

name

Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling

orthologousEvent

precedingEvent

[Reaction:R-HSA-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Homo sapiens

releaseDate 2005年09月26日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:203122] Heldin, CH, 2007年11月12日

revised

[InstanceEdit:9635710] Mi, Huaiyu, 2019年02月07日

schemaClass BlackBoxEvent

species

[Species:48887] Homo sapiens

stId R-HSA-201425

summation

[Summation:176007] The nuclear R-SMAD:Co-SMAD complex recruits ubiquitin conjug...

updateTrackers

Referrals

(updatedInstance)

(hasEvent)

[Pathway:R-HSA-201451] Signaling by BMP

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