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Schema
>
BlackBoxEvent
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Entries
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8
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authored
[InstanceEdit:202631] Huminiecki, L, Moustakas, A, 2007年11月07日 10:22:00
catalystActivity
[CatalystActivity:173534] ubiquitin protein ligase activity of SMURF [cytosol]
category
omitted
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:201460] Jassal, B, 2007年08月13日 08:42:05
dbId
201445
displayName
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8
eventOf
[Pathway:R-HSA-201451] Signaling by BMP - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:23767] negative regulation of BMP signaling pathway
input
[DefinedSet:R-HSA-201424] SMAD1/5/8 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:175938] Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase
[LiteratureReference:202636] A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
[LiteratureReference:202618] Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8
orthologousEvent
[BlackBoxEvent:R-DME-201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - Drosophila melanogaster
[BlackBoxEvent:R-GGA-201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - Gallus gallus
[BlackBoxEvent:R-XTR-201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - Xenopus tropicalis
[BlackBoxEvent:R-DRE-201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - Danio rerio
[BlackBoxEvent:R-SSC-201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - Sus scrofa
[BlackBoxEvent:R-BTA-201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - Bos taurus
[BlackBoxEvent:R-CFA-201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - Canis familiaris
[BlackBoxEvent:R-RNO-201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - Rattus norvegicus
[BlackBoxEvent:R-MMU-201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - Mus musculus
releaseDate
2005年09月26日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:203122] Heldin, CH, 2007年11月12日
revised
[InstanceEdit:9635710] Mi, Huaiyu, 2019年02月07日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-201445
summation
[Summation:176009] SMAD2 is polyubiquitinated by SMURF2 and targeted for protea...
updateTrackers
[UpdateTracker:9789145] Update Tracker - [BlackBoxEvent:201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - v38:[modifyText]
[UpdateTracker:9788609] Update Tracker - [BlackBoxEvent:201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - v41:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9789145] Update Tracker - [BlackBoxEvent:201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - v38:[modifyText]
[UpdateTracker:9788609] Update Tracker - [BlackBoxEvent:201445] Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 - v41:[modifyText]
(hasEvent)
[Pathway:R-HSA-201451] Signaling by BMP
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