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Schema
>
Reaction
>
Entries
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
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authored
[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006年10月10日
category
binding
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:199435] Jassal, B, 2007年07月10日 12:01:00
dbId
199443
displayName
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
edited
[InstanceEdit:2426555] Matthews, L, 2012年08月03日
eventOf
[Pathway:R-HSA-199418] Negative regulation of the PI3K/AKT network - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:263612] negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
input
[Complex:R-HSA-2317329] AKT:PIP3 [plasma membrane]
[DefinedSet:R-HSA-2400007] THEM4/TRIB3 [plasma membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:199446] Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane
[LiteratureReference:199452] TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver
maxDepth
1
modified
[InstanceEdit:10948619] Weiser, Joel, 2025年08月27日
name
THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
orthologousEvent
[Reaction:R-DDI-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - Dictyostelium discoideum
[Reaction:R-CEL-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - Caenorhabditis elegans
[Reaction:R-DME-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - Drosophila melanogaster
[Reaction:R-GGA-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - Gallus gallus
[Reaction:R-DRE-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - Danio rerio
[Reaction:R-RNO-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - Rattus norvegicus
[Reaction:R-MMU-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - Mus musculus
output
[Complex:R-HSA-199453] AKT:PIP3:THEM4/TRIB3 [plasma membrane]
releaseDate
2008年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:202668] Greene, LA, 2007年11月08日 15:39:37
[InstanceEdit:2463860] Thorpe, Lauren, 2012年08月13日
[InstanceEdit:2463859] Yuzugullu, Haluk, 2012年08月13日
[InstanceEdit:2463854] Zhao, Jean J, 2012年08月13日
revised
[InstanceEdit:2422427] Orlic-Milacic, M, 2012年07月18日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-199443
summation
[Summation:199427] The phosphorylation of membrane-recruited AKT at threonine a...
updateTrackers
[UpdateTracker:9789498] Update Tracker - [Reaction:199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - v38:[modifyText]
[UpdateTracker:9788437] Update Tracker - [Reaction:199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - v42:[add_removeInput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9789498] Update Tracker - [Reaction:199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - v38:[modifyText]
[UpdateTracker:9788437] Update Tracker - [Reaction:199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - v42:[add_removeInput, modifyText]
(hasEvent)
[Pathway:R-HSA-199418] Negative regulation of the PI3K/AKT network
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