Reactome Pathway Database

Schema > Reaction > Entries

THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation Show undefined attributes

category binding

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:10948619] Weiser, Joel, 2025年08月27日

dbId 10958236

displayName THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation

eventOf

[Pathway:R-DDI-199418] Negative regulation of the PI3K/AKT network - Dictyostelium discoideum

evidenceType [EvidenceType:9965817] inferred by electronic annotation

goBiologicalProcess [GO_BiologicalProcess:263612] negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

inferredFrom

[Reaction:R-HSA-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation

output

[Complex:R-DDI-199453] AKT:PIP3:THEM4/TRIB3 [plasma membrane]

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:170941] Dictyostelium discoideum

stId R-DDI-199443

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-DDI-199418] Negative regulation of the PI3K/AKT network

(inferredTo)

[Reaction:R-HSA-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation

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