Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
Negative regulation of the PI3K/AKT network
Show undefined attributes
Go to Details
authored
[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006年10月10日
created
[InstanceEdit:199435] Jassal, B, 2007年07月10日 12:01:00
crossReference
[DatabaseIdentifier:12757950] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:12757960] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12757962] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12757968] BioModels Database:BIOMD0000000651
[DatabaseIdentifier:12757970] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12757956] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12757972] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12757976] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12758018] BioModels Database:BIOMD0000000468
[DatabaseIdentifier:12757982] BioModels Database:BIOMD0000000424
[DatabaseIdentifier:12757984] BioModels Database:BIOMD0000000654
dbId
199418
displayName
Negative regulation of the PI3K/AKT network
eventOf
[Pathway:R-HSA-1257604] PIP3 activates AKT signaling - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-199456] PTEN dephosphorylates PIP3 - Homo sapiens
[Reaction:R-HSA-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - Homo sapiens
[Reaction:R-HSA-199425] PHLPP dephosphorylates S473 in AKT - Homo sapiens
[Pathway:R-HSA-6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2017年06月22日
maxDepth
3
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Negative regulation of the PI3K/AKT network
orthologousEvent
[Pathway:R-PFA-199418] Negative regulation of the PI3K/AKT network - Plasmodium falciparum
[Pathway:R-SCE-199418] Negative regulation of the PI3K/AKT network - Saccharomyces cerevisiae
[Pathway:R-SPO-199418] Negative regulation of the PI3K/AKT network - Schizosaccharomyces pombe
[Pathway:R-DDI-199418] Negative regulation of the PI3K/AKT network - Dictyostelium discoideum
[Pathway:R-CEL-199418] Negative regulation of the PI3K/AKT network - Caenorhabditis elegans
[Pathway:R-DME-199418] Negative regulation of the PI3K/AKT network - Drosophila melanogaster
[Pathway:R-GGA-199418] Negative regulation of the PI3K/AKT network - Gallus gallus
[Pathway:R-XTR-199418] Negative regulation of the PI3K/AKT network - Xenopus tropicalis
[Pathway:R-DRE-199418] Negative regulation of the PI3K/AKT network - Danio rerio
[Pathway:R-SSC-199418] Negative regulation of the PI3K/AKT network - Sus scrofa
[Pathway:R-BTA-199418] Negative regulation of the PI3K/AKT network - Bos taurus
[Pathway:R-CFA-199418] Negative regulation of the PI3K/AKT network - Canis familiaris
[Pathway:R-RNO-199418] Negative regulation of the PI3K/AKT network - Rattus norvegicus
[Pathway:R-MMU-199418] Negative regulation of the PI3K/AKT network - Mus musculus
releaseDate
2008年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:202668] Greene, LA, 2007年11月08日 15:39:37
[InstanceEdit:2463860] Thorpe, Lauren, 2012年08月13日
[InstanceEdit:2463859] Yuzugullu, Haluk, 2012年08月13日
[InstanceEdit:2463854] Zhao, Jean J, 2012年08月13日
revised
[InstanceEdit:2327847] Orlic-Milacic, M, 2012年06月21日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-199418
summation
[Summation:211747] The PI3K/AKT network is negatively regulated by phosphatases...
updateTrackers
[UpdateTracker:9788377] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v42:[updateContainedRLE]
[UpdateTracker:9782242] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v59:[updateContainedRLE]
[UpdateTracker:9783212] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v57:[updateContainedRLE]
[UpdateTracker:9783721] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v56:[addHasEvent]
[UpdateTracker:9789242] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v38:[updateContainedRLE]
[UpdateTracker:9781251] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v61:[updateIndirectRLE]
Referrals
(updatedInstance)
[UpdateTracker:9788377] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v42:[updateContainedRLE]
[UpdateTracker:9782242] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v59:[updateContainedRLE]
[UpdateTracker:9783212] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v57:[updateContainedRLE]
[UpdateTracker:9783721] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v56:[addHasEvent]
[UpdateTracker:9789242] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v38:[updateContainedRLE]
[UpdateTracker:9781251] Update Tracker - [Pathway:199418] Negative regulation of the PI3K/AKT network - v61:[updateIndirectRLE]
(hasEvent)
[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル