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Schema
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Pathway
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Entries
Signaling by NOTCH1
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authored
[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011年11月14日
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created
[InstanceEdit:1980144] Orlic-Milacic, M, 2011年11月08日
dbId
1980143
diseasePathways
[Pathway:R-HSA-2691230] Signaling by NOTCH1 HD Domain Mutants in Cancer - Homo sapiens
[Pathway:R-HSA-2894858] Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer - Homo sapiens
[Pathway:R-HSA-2644605] FBXW7 Mutants and NOTCH1 in Cancer - Homo sapiens
[Pathway:R-HSA-2644602] Signaling by NOTCH1 PEST Domain Mutants in Cancer - Homo sapiens
[Pathway:R-HSA-2660825] Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant - Homo sapiens
displayName
Signaling by NOTCH1
doi
10.3180/REACT_118859.1
edited
[InstanceEdit:2106576] Orlic-Milacic, M, 2012年02月10日
[InstanceEdit:2098673] D'Eustachio, P, 2012年02月06日
eventOf
[Pathway:R-HSA-157118] Signaling by NOTCH - Homo sapiens
figure
[Figure:2291899] /figures/Pathway_Illustrations/NOTCH1_72_oicr.png
goBiologicalProcess
[GO_BiologicalProcess:20089] Notch signaling pathway
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Homo sapiens
[Pathway:R-HSA-2122947] NOTCH1 Intracellular Domain Regulates Transcription - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2020年03月16日
literatureReference
[LiteratureReference:2046385] Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity
[LiteratureReference:186662] Delta-1 activation of notch-1 signaling results in HES-1 transactivation
[LiteratureReference:2050621] The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
[LiteratureReference:2053957] The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1
[LiteratureReference:157224] Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor
[LiteratureReference:2053968] Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors
[LiteratureReference:2050520] Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1
[LiteratureReference:1602210] An obligatory role of mind bomb-1 in notch signaling of mammalian development
[LiteratureReference:1602191] Mind bomb-2 is an E3 ligase for Notch ligand
[LiteratureReference:2084252] Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1
[LiteratureReference:1602202] Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta
[LiteratureReference:208133] Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta
[LiteratureReference:2084254] Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1
[LiteratureReference:2059852] Metalloprotease ADAM10 is required for Notch1 site 2 cleavage
[LiteratureReference:157210] A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE
[LiteratureReference:2059841] The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts
[LiteratureReference:2059844] Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
[LiteratureReference:163904] A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
[LiteratureReference:163911] Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
[LiteratureReference:163903] Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
[LiteratureReference:2063949] A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
[LiteratureReference:351549] SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function
[LiteratureReference:383069] A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors
[LiteratureReference:2063951] TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints
[LiteratureReference:351538] Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
[LiteratureReference:2064894] p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro
[LiteratureReference:208099] Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
[LiteratureReference:1602204] Signalling downstream of activated mammalian Notch
[LiteratureReference:1911382] Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes
[LiteratureReference:1911389] The Notch target genes Hey1 and Hey2 are required for embryonic vascular development
[LiteratureReference:1890288] Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos
[LiteratureReference:2065301] Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes
[LiteratureReference:1602205] NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
[LiteratureReference:2065503] Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif
[LiteratureReference:2065501] The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain
[LiteratureReference:2065514] Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
[LiteratureReference:351516] Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
[LiteratureReference:2064850] The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
[LiteratureReference:2064869] SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
[LiteratureReference:2064874] FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
[LiteratureReference:1604416] Hypoxia requires notch signaling to maintain the undifferentiated cell state
[LiteratureReference:373542] F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
[LiteratureReference:1890294] DNER acts as a neuron-specific Notch ligand during Bergmann glial development
[LiteratureReference:1602194] Human deltex is a conserved regulator of Notch signalling
[LiteratureReference:1602199] Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis
[LiteratureReference:1911367] Regulation of Notch signalling by non-visual beta-arrestin
[LiteratureReference:1602188] Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains
[LiteratureReference:2076204] Cis-interactions between Notch and Delta generate mutually exclusive signalling states
[LiteratureReference:1602201] dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats
[LiteratureReference:1602211] The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila
[LiteratureReference:2077480] Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells
[LiteratureReference:1602206] Numb regulates post-endocytic trafficking and degradation of Notch1
[LiteratureReference:1602207] AIP4/Itch regulates Notch receptor degradation in the absence of ligand
maxDepth
3
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
Signaling by NOTCH1
orthologousEvent
[Pathway:R-MMU-1980143] Signaling by NOTCH1 - Mus musculus
[Pathway:R-RNO-1980143] Signaling by NOTCH1 - Rattus norvegicus
[Pathway:R-CFA-1980143] Signaling by NOTCH1 - Canis familiaris
[Pathway:R-BTA-1980143] Signaling by NOTCH1 - Bos taurus
[Pathway:R-SSC-1980143] Signaling by NOTCH1 - Sus scrofa
[Pathway:R-DRE-1980143] Signaling by NOTCH1 - Danio rerio
[Pathway:R-XTR-1980143] Signaling by NOTCH1 - Xenopus tropicalis
[Pathway:R-GGA-1980143] Signaling by NOTCH1 - Gallus gallus
[Pathway:R-DME-1980143] Signaling by NOTCH1 - Drosophila melanogaster
releaseDate
2012年03月13日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2121207] Haw, R, 2012年02月06日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-1980143
summation
[Summation:2084260] NOTCH1 functions as both a transmembrane receptor presented ...
updateTrackers
[UpdateTracker:9777142] Update Tracker - [Pathway:1980143] Signaling by NOTCH1 - v72:[updateContainedPathway]
[UpdateTracker:9788632] Update Tracker - [Pathway:1980143] Signaling by NOTCH1 - v41:[modifyText, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9787765] Update Tracker - [Pathway:1980143] Signaling by NOTCH1 - v44:[updateIndirectRLE]
[UpdateTracker:9780698] Update Tracker - [Pathway:1980143] Signaling by NOTCH1 - v62:[modifyText]
[UpdateTracker:9782371] Update Tracker - [Pathway:1980143] Signaling by NOTCH1 - v59:[updateIndirectRLE]
[UpdateTracker:9787129] Update Tracker - [Pathway:1980143] Signaling by NOTCH1 - v46:[updateContainedPathway, updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-157118] Signaling by NOTCH
(hasEncapsulatedEvent)
[Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1
[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2
[Pathway:R-HSA-8878159] Transcriptional regulation by RUNX3
[Pathway:R-HSA-1912422] Pre-NOTCH Expression and Processing
[Pathway:R-HSA-1980145] Signaling by NOTCH2
(normalPathway)
[Pathway:R-HSA-2691230] Signaling by NOTCH1 HD Domain Mutants in Cancer
[Pathway:R-HSA-2894858] Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
[Pathway:R-HSA-2644605] FBXW7 Mutants and NOTCH1 in Cancer
[Pathway:R-HSA-2644602] Signaling by NOTCH1 PEST Domain Mutants in Cancer
[Pathway:R-HSA-2660825] Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
(updatedInstance)
[UpdateTracker:9777142] Update Tracker - [Pathway:1980143] Signaling by NOTCH1 - v72:[updateContainedPathway]
[UpdateTracker:9788632] Update Tracker - [Pathway:1980143] Signaling by NOTCH1 - v41:[modifyText, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9787765] Update Tracker - [Pathway:1980143] Signaling by NOTCH1 - v44:[updateIndirectRLE]
[UpdateTracker:9780698] Update Tracker - [Pathway:1980143] Signaling by NOTCH1 - v62:[modifyText]
[UpdateTracker:9782371] Update Tracker - [Pathway:1980143] Signaling by NOTCH1 - v59:[updateIndirectRLE]
[UpdateTracker:9787129] Update Tracker - [Pathway:1980143] Signaling by NOTCH1 - v46:[updateContainedPathway, updateIndirectRLE]
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