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Entries
Pre-NOTCH Expression and Processing
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authored
[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011年11月14日
compartment
[Compartment:7660] nucleoplasm
[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:17957] endoplasmic reticulum lumen
[Compartment:20699] Golgi membrane
[Compartment:17963] Golgi lumen
[Compartment:876] plasma membrane
created
[InstanceEdit:1912421] Orlic-Milacic, M, 2011年11月01日
dbId
1912422
diseasePathways
[Pathway:R-HSA-5083630] Defective LFNG causes SCDO3 - Homo sapiens
displayName
Pre-NOTCH Expression and Processing
doi
10.3180/REACT_118744.1
edited
[InstanceEdit:2106576] Orlic-Milacic, M, 2012年02月10日
[InstanceEdit:2098673] D'Eustachio, P, 2012年02月06日
eventOf
[Pathway:R-HSA-157118] Signaling by NOTCH - Homo sapiens
figure
[Figure:2291914] /figures/Pathway_Illustrations/Pre-NOTCH_72_oicr.png
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-1912408] Pre-NOTCH Transcription and Translation - Homo sapiens
[Pathway:R-HSA-1912399] Pre-NOTCH Processing in the Endoplasmic Reticulum - Homo sapiens
[Pathway:R-HSA-1912420] Pre-NOTCH Processing in Golgi - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2021年09月15日
literatureReference
[LiteratureReference:1606697] MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes
[LiteratureReference:1606693] MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells
[LiteratureReference:1606696] MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
[LiteratureReference:1888217] Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells
[LiteratureReference:1606546] Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway
[LiteratureReference:1892027] Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150
[LiteratureReference:1890323] MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation
[LiteratureReference:1890316] Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis
[LiteratureReference:1890304] Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment
[LiteratureReference:1602200] Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions
[LiteratureReference:1602192] Roles of Pofut1 and O-fucose in mammalian Notch signaling
[LiteratureReference:2152308] Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila
[LiteratureReference:1602208] Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase
[LiteratureReference:1984028] Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region
[LiteratureReference:1602203] Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling
[LiteratureReference:1602212] Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi
[LiteratureReference:1602189] Glycosyltransferase activity of Fringe modulates Notch-Delta interactions
[LiteratureReference:208198] Fringe is a glycosyltransferase that modifies Notch
[LiteratureReference:2023165] A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway
[LiteratureReference:1602195] Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1
[LiteratureReference:157138] Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
[LiteratureReference:157112] The Notch1 receptor is cleaved constitutively by a furin-like convertase
[LiteratureReference:2033398] Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2
[LiteratureReference:157059] Calcium depletion dissociates and activates heterodimeric notch receptors
[LiteratureReference:157123] Roles for proteolysis and trafficking in notch maturation and signal transduction
maxDepth
4
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Pre-NOTCH Expression and Processing
orthologousEvent
[Pathway:R-CEL-1912422] Pre-NOTCH Expression and Processing - Caenorhabditis elegans
[Pathway:R-MMU-1912422] Pre-NOTCH Expression and Processing - Mus musculus
[Pathway:R-RNO-1912422] Pre-NOTCH Expression and Processing - Rattus norvegicus
[Pathway:R-CFA-1912422] Pre-NOTCH Expression and Processing - Canis familiaris
[Pathway:R-BTA-1912422] Pre-NOTCH Expression and Processing - Bos taurus
[Pathway:R-SSC-1912422] Pre-NOTCH Expression and Processing - Sus scrofa
[Pathway:R-XTR-1912422] Pre-NOTCH Expression and Processing - Xenopus tropicalis
[Pathway:R-GGA-1912422] Pre-NOTCH Expression and Processing - Gallus gallus
[Pathway:R-DME-1912422] Pre-NOTCH Expression and Processing - Drosophila melanogaster
releaseDate
2012年03月13日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2121207] Haw, R, 2012年02月06日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-1912422
summation
[Summation:2043923] In humans and other mammals the NOTCH gene family has four m...
updateTrackers
[UpdateTracker:9787173] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v46:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9780225] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9783455] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v56:[updateIndirectRLE]
[UpdateTracker:9775826] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v78:[updateIndirectRLE]
[UpdateTracker:9788517] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v41:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9781614] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v60:[updateIndirectRLE]
[UpdateTracker:9779599] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v65:[updateContainedPathway]
Referrals
(hasEvent)
[Pathway:R-HSA-157118] Signaling by NOTCH
(hasEncapsulatedEvent)
[Pathway:R-HSA-8986944] Transcriptional Regulation by MECP2
[Pathway:R-HSA-1980143] Signaling by NOTCH1
[Pathway:R-HSA-1980145] Signaling by NOTCH2
(normalPathway)
[Pathway:R-HSA-5083630] Defective LFNG causes SCDO3
(updatedInstance)
[UpdateTracker:9787173] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v46:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9780225] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v63:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9783455] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v56:[updateIndirectRLE]
[UpdateTracker:9775826] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v78:[updateIndirectRLE]
[UpdateTracker:9788517] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v41:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9781614] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v60:[updateIndirectRLE]
[UpdateTracker:9779599] Update Tracker - [Pathway:1912422] Pre-NOTCH Expression and Processing - v65:[updateContainedPathway]
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