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Schema
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Pathway
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Entries
Signaling by NOTCH2
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authored
[InstanceEdit:157021] Jassal, B, 2004年12月15日 13:08:03
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created
[InstanceEdit:1980146] Orlic-Milacic, M, 2011年11月08日
dbId
1980145
displayName
Signaling by NOTCH2
doi
10.3180/REACT_118721.4
edited
[InstanceEdit:2106576] Orlic-Milacic, M, 2012年02月10日
eventOf
[Pathway:R-HSA-157118] Signaling by NOTCH - Homo sapiens
figure
[Figure:2291902] /figures/Pathway_Illustrations/NOTCH2_72_oicr.png
goBiologicalProcess
[GO_BiologicalProcess:20089] Notch signaling pathway
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus - Homo sapiens
[Pathway:R-HSA-2197563] NOTCH2 intracellular domain regulates transcription - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2018年09月30日
literatureReference
[LiteratureReference:157133] Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2
[LiteratureReference:2168111] Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
[LiteratureReference:2169058] Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods
[LiteratureReference:2168113] Function of Delta4 gene and its effects on 32D cell differentiation
[LiteratureReference:2172161] ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo
[LiteratureReference:2197549] Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis
[LiteratureReference:163904] A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
[LiteratureReference:2025785] Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells
[LiteratureReference:2974760] Notch signaling activated by replication stress-induced expression of midkine drives epithelial-mesenchymal transition and chemoresistance in pancreatic cancer
[LiteratureReference:373542] F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
[LiteratureReference:2974758] Midkine induces epithelial-mesenchymal transition through Notch2/Jak2-Stat3 signaling in human keratinocytes
[LiteratureReference:2127284] Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia
[LiteratureReference:2976559] Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity
[LiteratureReference:2025784] NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway
[LiteratureReference:2197547] Functional diversity among Notch1, Notch2, and Notch3 receptors
[LiteratureReference:2197584] MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
[LiteratureReference:1497893] The canonical Notch signaling pathway: unfolding the activation mechanism
[LiteratureReference:2153481] Canonical and non-canonical Notch ligands
[LiteratureReference:3321790] Mechanistic insights into Notch receptor signaling from structural and biochemical studies
[LiteratureReference:3322874] Hepatic ductular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental, and sexual development, and cardiac murmur
[LiteratureReference:3322873] Mutations in the human Jagged1 gene are responsible for Alagille syndrome
[LiteratureReference:3322887] Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
[LiteratureReference:3322899] Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss
[LiteratureReference:3322922] Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis
[LiteratureReference:3322890] Mutations in NOTCH2 in families with Hajdu-Cheney syndrome
maxDepth
3
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
Signaling by NOTCH2
orthologousEvent
[Pathway:R-MMU-1980145] Signaling by NOTCH2 - Mus musculus
[Pathway:R-RNO-1980145] Signaling by NOTCH2 - Rattus norvegicus
[Pathway:R-CFA-1980145] Signaling by NOTCH2 - Canis familiaris
[Pathway:R-BTA-1980145] Signaling by NOTCH2 - Bos taurus
[Pathway:R-SSC-1980145] Signaling by NOTCH2 - Sus scrofa
[Pathway:R-DRE-1980145] Signaling by NOTCH2 - Danio rerio
[Pathway:R-XTR-1980145] Signaling by NOTCH2 - Xenopus tropicalis
[Pathway:R-GGA-1980145] Signaling by NOTCH2 - Gallus gallus
[Pathway:R-DME-1980145] Signaling by NOTCH2 - Drosophila melanogaster
releaseDate
2005年06月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:165114] Joutel, A, 2004年12月15日
[InstanceEdit:3448657] Boyle, Scott, 2013年04月25日
[InstanceEdit:3448655] Ilagan, Ma Xenia, 2013年04月25日
revised
[InstanceEdit:2980678] Orlic-Milacic, M, 2013年01月11日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-1980145
summation
[Summation:2122955] NOTCH2 is activated by binding Delta-like and Jagged ligands...
updateTrackers
[UpdateTracker:9788053] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v44:[addLiteratureReference, add_removeHasEvent, modifyText]
[UpdateTracker:9788699] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v41:[updateContainedRLE]
[UpdateTracker:9779050] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v66:[updateIndirectRLE]
[UpdateTracker:9780758] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v62:[updateIndirectRLE]
[UpdateTracker:9787399] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v45:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-157118] Signaling by NOTCH
(hasEncapsulatedEvent)
[Pathway:R-HSA-1912422] Pre-NOTCH Expression and Processing
(updatedInstance)
[UpdateTracker:9788053] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v44:[addLiteratureReference, add_removeHasEvent, modifyText]
[UpdateTracker:9788699] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v41:[updateContainedRLE]
[UpdateTracker:9779050] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v66:[updateIndirectRLE]
[UpdateTracker:9780758] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v62:[updateIndirectRLE]
[UpdateTracker:9787399] Update Tracker - [Pathway:1980145] Signaling by NOTCH2 - v45:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateIndirectRLE]
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