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Reaction
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Entries
PANK2 phosphorylates PanK
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authored
[InstanceEdit:196747] Jassal, B, 2007年04月24日 08:38:46
catalystActivity
[CatalystActivity:196799] pantothenate kinase activity of PANK2(111-570) [mitochondrial intermembrane space]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:17927] mitochondrial intermembrane space
created
[InstanceEdit:196747] Jassal, B, 2007年04月24日 08:38:46
crossReference
[DatabaseIdentifier:12611236] Rhea:16374
dbId
196857
displayName
PANK2 phosphorylates PanK
eventOf
[Pathway:R-HSA-196783] Coenzyme A biosynthesis - Homo sapiens
followingEvent
[Reaction:R-HSA-196753] 2xPPCS ligates PPanK with Cys - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-196820] PanK [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:196762] An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria
[LiteratureReference:196739] Mitochondrial localization of human PANK2 and hypotheses of secondary iron accumulation in pantothenate kinase-associated neurodegeneration
[LiteratureReference:199239] Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine
[LiteratureReference:9837293] Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters
[LiteratureReference:196771] Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration
[LiteratureReference:199209] A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
PANK2 phosphorylates PanK
(R)-pantothenate + ATP => (R)-4'-phosphopantothenate + ADP + H(+)
orthologousEvent
[Reaction:R-DME-196857] PANK2 phosphorylates PanK - Drosophila melanogaster
[Reaction:R-GGA-196857] PANK2 phosphorylates PanK - Gallus gallus
[Reaction:R-XTR-196857] PANK2 phosphorylates PanK - Xenopus tropicalis
[Reaction:R-SSC-196857] PANK2 phosphorylates PanK - Sus scrofa
[Reaction:R-BTA-196857] PANK2 phosphorylates PanK - Bos taurus
[Reaction:R-CFA-196857] PANK2 phosphorylates PanK - Canis familiaris
[Reaction:R-RNO-196857] PANK2 phosphorylates PanK - Rattus norvegicus
[Reaction:R-MMU-196857] PANK2 phosphorylates PanK - Mus musculus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-196786] PPanK [cytosol]
precedingEvent
[Reaction:R-HSA-199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
regulatedBy
[NegativeRegulation:9837290] Negative regulation by 'CoA-SH [cytosol]'
regulationReference
[RegulationReference:9837286] Negative regulation by 'CoA-SH [cytosol]' Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters
releaseDate
2007年09月04日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9840788] Hill, David P, 2023年07月26日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-196857
summation
[Summation:196776] Pantothenate kinase 2 (PANK2) catalyzes the reaction of ATP ...
updateTrackers
[UpdateTracker:9842331] Update Tracker - [Reaction:196857] PANK2 phosphorylates PanK - v86:[addLiteratureReference, addOutput, addRegulator, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9842331] Update Tracker - [Reaction:196857] PANK2 phosphorylates PanK - v86:[addLiteratureReference, addOutput, addRegulator, modifyText]
(hasEvent)
[Pathway:R-HSA-196783] Coenzyme A biosynthesis
(precedingEvent)
[Reaction:R-HSA-196753] 2xPPCS ligates PPanK with Cys
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