Reactome Pathway Database

Schema > Reaction > Entries

PANK2 phosphorylates PanK Show undefined attributes

catalystActivity

[CatalystActivity:10792347] pantothenate kinase activity of PANK2(111-570) [mitochondrial intermembrane space]

category transition

compartment

created [InstanceEdit:10778922] Weiser, Joel, 2025年08月27日

dbId 10792349

displayName PANK2 phosphorylates PanK

eventOf

[Pathway:R-DME-196783] Coenzyme A biosynthesis - Drosophila melanogaster

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-DME-196753] 2xPPCS ligates PPanK with Cys - Drosophila melanogaster

inferredFrom

[Reaction:R-HSA-196857] PANK2 phosphorylates PanK - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

PANK2 phosphorylates PanK
(R)-pantothenate + ATP => (R)-4'-phosphopantothenate + ADP + H(+)

output

regulatedBy

[NegativeRegulation:9837290] Negative regulation by 'CoA-SH [cytosol]'

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:56210] Drosophila melanogaster

stId R-DME-196857

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-DME-196783] Coenzyme A biosynthesis

(precedingEvent)

[Reaction:R-DME-196753] 2xPPCS ligates PPanK with Cys

(inferredTo)

[Reaction:R-HSA-196857] PANK2 phosphorylates PanK

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