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Schema > Reaction > Entries

2xPPCS ligates PPanK with Cys Show undefined attributes

catalystActivity

[CatalystActivity:10792319] phosphopantothenate--cysteine ligase activity of 2xPPCS [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10778922] Weiser, Joel, 2025年08月27日

dbId 10792321

displayName 2xPPCS ligates PPanK with Cys

eventOf

[Pathway:R-DME-196783] Coenzyme A biosynthesis - Drosophila melanogaster

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-DME-196840] 3xPPCDC:3FMN decarboxylates PPC - Drosophila melanogaster

inferredFrom

[Reaction:R-HSA-196753] 2xPPCS ligates PPanK with Cys - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

2xPPCS ligates PPanK with Cys
(R)-4'-phosphopantothenate + ATP + L-cysteine => AMP + diphosphate + H(+) + N-((R)-4-phosphopantothenoyl)-L-cysteine

output

precedingEvent

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:56210] Drosophila melanogaster

stId R-DME-196753

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-DME-196783] Coenzyme A biosynthesis

(precedingEvent)

[Reaction:R-DME-196840] 3xPPCDC:3FMN decarboxylates PPC

(inferredTo)

[Reaction:R-HSA-196753] 2xPPCS ligates PPanK with Cys

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