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Entries
SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol
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authored
[InstanceEdit:199189] D'Eustachio, P, 2007年07月09日 22:03:12
catalystActivity
[CatalystActivity:199212] sodium-dependent multivitamin transmembrane transporter activity of SLC5A6:PDZD11 [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9837298] sodium-dependent multivitamin transmembrane transporter activity of SLC5A6:PDZD11 [plasma membrane] Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:199189] D'Eustachio, P, 2007年07月09日 22:03:12
crossReference
[DatabaseIdentifier:12611237] Rhea:73371
dbId
199206
displayName
SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol
eventOf
[Pathway:R-HSA-199220] Vitamin B5 (pantothenate) metabolism - Homo sapiens
followingEvent
[Reaction:R-HSA-196857] PANK2 phosphorylates PanK - Homo sapiens
[Reaction:R-HSA-199203] PANK1/3 phosphorylate PanK - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-74113] Na+ [extracellular region]
[SimpleEntity:R-ALL-199192] PanK [extracellular region]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5359001] Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter
[LiteratureReference:9837288] Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate
[LiteratureReference:199217] Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter
[LiteratureReference:199231] Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization.
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol
(R)-pantothenate(out) + 2 Na(+)(out) = (R)-pantothenate(in) + 2 Na(+)(in)
orthologousEvent
[Reaction:R-GGA-199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - Gallus gallus
[Reaction:R-XTR-199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - Xenopus tropicalis
[Reaction:R-DRE-199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - Danio rerio
[Reaction:R-SSC-199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - Sus scrofa
[Reaction:R-BTA-199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - Bos taurus
[Reaction:R-CFA-199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - Canis familiaris
[Reaction:R-RNO-199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - Rattus norvegicus
[Reaction:R-MMU-199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - Mus musculus
output
2 ×
[SimpleEntity:R-ALL-83910] Na+ [cytosol]
[SimpleEntity:R-ALL-196820] PanK [cytosol]
releaseDate
2007年09月04日
reviewStatus
[ReviewStatus:9821382] five stars
revised
[InstanceEdit:5359004] Jassal, Bijay, 2014年04月07日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-199206
summation
[Summation:199226] The plasma membrane-associated transport protein SLC5A6 (SMV...
updateTrackers
[UpdateTracker:9787821] Update Tracker - [Reaction:199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - v44:[modifyText]
[UpdateTracker:9842329] Update Tracker - [Reaction:199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - v86:[addLiteratureReference, modifyText]
[UpdateTracker:9786487] Update Tracker - [Reaction:199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - v49:[addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9787821] Update Tracker - [Reaction:199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - v44:[modifyText]
[UpdateTracker:9842329] Update Tracker - [Reaction:199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - v86:[addLiteratureReference, modifyText]
[UpdateTracker:9786487] Update Tracker - [Reaction:199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - v49:[addLiteratureReference, modifyText]
(hasEvent)
[Pathway:R-HSA-199220] Vitamin B5 (pantothenate) metabolism
(precedingEvent)
[Reaction:R-HSA-196857] PANK2 phosphorylates PanK
[Reaction:R-HSA-199203] PANK1/3 phosphorylate PanK
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