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Schema
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Entries
Two FPP molecules dimerize to form presqualene diphosphate
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authored
[InstanceEdit:191754] Jassal, B, 2007年01月24日 15:15:12
catalystActivity
[CatalystActivity:191305] squalene synthase [NAD(P)H] activity of FDFT:Mg2+ [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:191331] Jassal, Bijay, 2007年01月19日
crossReference
[DatabaseIdentifier:12610957] Rhea:22673
[DatabaseIdentifier:9945097] RHEA:22673
dbId
191405
displayName
Two FPP molecules dimerize to form presqualene diphosphate
eventOf
[Pathway:R-HSA-191273] Cholesterol biosynthesis - Homo sapiens
followingEvent
[Reaction:R-HSA-8952137] Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate - Homo sapiens
[Reaction:R-HSA-191402] Reduction of presqualene diphosphate to form squalene - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-191385] FAPP [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:201364] Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
Two FPP molecules dimerize to form presqualene diphosphate
2 (2E,6E)-farnesyl diphosphate => presqualene diphosphate + diphosphate
orthologousEvent
[Reaction:R-SCE-191405] Two FPP molecules dimerize to form presqualene diphosphate - Saccharomyces cerevisiae
[Reaction:R-SPO-191405] Two FPP molecules dimerize to form presqualene diphosphate - Schizosaccharomyces pombe
[Reaction:R-DDI-191405] Two FPP molecules dimerize to form presqualene diphosphate - Dictyostelium discoideum
[Reaction:R-GGA-191405] Two FPP molecules dimerize to form presqualene diphosphate - Gallus gallus
[Reaction:R-XTR-191405] Two FPP molecules dimerize to form presqualene diphosphate - Xenopus tropicalis
[Reaction:R-SSC-191405] Two FPP molecules dimerize to form presqualene diphosphate - Sus scrofa
[Reaction:R-BTA-191405] Two FPP molecules dimerize to form presqualene diphosphate - Bos taurus
[Reaction:R-CFA-191405] Two FPP molecules dimerize to form presqualene diphosphate - Canis familiaris
[Reaction:R-RNO-191405] Two FPP molecules dimerize to form presqualene diphosphate - Rattus norvegicus
[Reaction:R-MMU-191405] Two FPP molecules dimerize to form presqualene diphosphate - Mus musculus
output
[SimpleEntity:R-ALL-111294] PPi [cytosol]
[SimpleEntity:R-ALL-191265] PSQPP [cytosol]
precedingEvent
[Reaction:R-HSA-191303] FDPS dimer transfers IPPP to GPP - Homo sapiens
[Reaction:R-HSA-9717830] GGPS1 hexamer transfers IPPP to GPP - Homo sapiens
releaseDate
2007年02月20日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:191591] D'Eustachio, P, 2007年01月22日 01:32:07
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-191405
summation
[Summation:191347] Farnesyl diphosphate farnesyltransferase (FDFT; squalene syn...
updateTrackers
[UpdateTracker:9792364] Update Tracker - [Reaction:191405] Two FPP molecules dimerize to form presqualene diphosphate - v22:[addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9792364] Update Tracker - [Reaction:191405] Two FPP molecules dimerize to form presqualene diphosphate - v22:[addLiteratureReference, modifyText]
(hasEvent)
[Pathway:R-HSA-191273] Cholesterol biosynthesis
(precedingEvent)
[Reaction:R-HSA-8952137] Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate
[Reaction:R-HSA-191402] Reduction of presqualene diphosphate to form squalene
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