Reactome Pathway Database

Schema > Reaction > Entries

Two FPP molecules dimerize to form presqualene diphosphate Show undefined attributes

catalystActivity

[CatalystActivity:10216836] squalene synthase [NAD(P)H] activity of FDFT:Mg2+ [endoplasmic reticulum membrane]

category transition

compartment

created [InstanceEdit:10201029] Weiser, Joel, 2025年08月27日

dbId 10216840

displayName Two FPP molecules dimerize to form presqualene diphosphate

eventOf

[Pathway:R-CFA-191273] Cholesterol biosynthesis - Canis familiaris

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

inferredFrom

[Reaction:R-HSA-191405] Two FPP molecules dimerize to form presqualene diphosphate - Homo sapiens

input

2 × [SimpleEntity:R-ALL-191385] FAPP [cytosol]

isInDisease false

isInferred true

maxDepth 1

name

Two FPP molecules dimerize to form presqualene diphosphate
2 (2E,6E)-farnesyl diphosphate => presqualene diphosphate + diphosphate

output

precedingEvent

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49646] Canis familiaris

stId R-CFA-191405

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-CFA-191273] Cholesterol biosynthesis

(precedingEvent)

(inferredTo)

[Reaction:R-HSA-191405] Two FPP molecules dimerize to form presqualene diphosphate

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