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Entries
GGPS1 hexamer transfers IPPP to GPP
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authored
[InstanceEdit:191754] Jassal, B, 2007年01月24日 15:15:12
catalystActivity
[CatalystActivity:9717839] (2E,6E)-farnesyl diphosphate synthase activity of holo-GGPS1 hexamer [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9717837] Jassal, Bijay, 2021年03月15日
crossReference
[DatabaseIdentifier:12610958] Rhea:19362
[DatabaseIdentifier:9945085] RHEA:19362
dbId
9717830
displayName
GGPS1 hexamer transfers IPPP to GPP
edited
[InstanceEdit:191754] Jassal, B, 2007年01月24日 15:15:12
eventOf
[Pathway:R-HSA-191273] Cholesterol biosynthesis - Homo sapiens
followingEvent
[Reaction:R-HSA-191405] Two FPP molecules dimerize to form presqualene diphosphate - Homo sapiens
input
[SimpleEntity:R-ALL-191409] GPP [cytosol]
[SimpleEntity:R-ALL-191362] IPPP [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:191398] Human geranylgeranyl diphosphate synthase. cDNA cloning and expression.
[LiteratureReference:191275] Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression
[LiteratureReference:981558] The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
GGPS1 hexamer transfers IPPP to GPP
isopentenyl diphosphate + (2E)-geranyl diphosphate => (2E,6E)-farnesyl diphosphate + diphosphate
Another isopentenyl pyrophosphate is added to geranyl pyrophosphate
orthologousEvent
[Reaction:R-SCE-9717830] GGPS1 hexamer transfers IPPP to GPP - Saccharomyces cerevisiae
[Reaction:R-DDI-9717830] GGPS1 hexamer transfers IPPP to GPP - Dictyostelium discoideum
[Reaction:R-DME-9717830] GGPS1 hexamer transfers IPPP to GPP - Drosophila melanogaster
[Reaction:R-GGA-9717830] GGPS1 hexamer transfers IPPP to GPP - Gallus gallus
[Reaction:R-XTR-9717830] GGPS1 hexamer transfers IPPP to GPP - Xenopus tropicalis
[Reaction:R-SSC-9717830] GGPS1 hexamer transfers IPPP to GPP - Sus scrofa
[Reaction:R-BTA-9717830] GGPS1 hexamer transfers IPPP to GPP - Bos taurus
[Reaction:R-CFA-9717830] GGPS1 hexamer transfers IPPP to GPP - Canis familiaris
[Reaction:R-RNO-9717830] GGPS1 hexamer transfers IPPP to GPP - Rattus norvegicus
[Reaction:R-MMU-9717830] GGPS1 hexamer transfers IPPP to GPP - Mus musculus
output
[SimpleEntity:R-ALL-191385] FAPP [cytosol]
[SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent
[Reaction:R-HSA-9717834] GGPS1 hexamer transfers IPPP to DMAPP - Homo sapiens
[Reaction:R-HSA-191322] FDPS dimer transfers IPPP to DMAPP - Homo sapiens
[Reaction:R-HSA-191414] MVD decarboxylates MVA5PP to IPPP - Homo sapiens
releaseDate
2007年02月20日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:191591] D'Eustachio, P, 2007年01月22日 01:32:07
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9717830
summation
[Summation:191267] Further condensation of an isopentenyl pyrophosphate (IPPP) ...
Referrals
(hasEvent)
[Pathway:R-HSA-191273] Cholesterol biosynthesis
(precedingEvent)
[Reaction:R-HSA-191405] Two FPP molecules dimerize to form presqualene diphosphate
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