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Entries
Activation of ATR in response to replication stress
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authored
[InstanceEdit:176227] Borowiec, JA, 2006年02月25日 17:40:15
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:176246] D'Eustachio, P, 2006年03月03日 16:44:08
crossReference
[DatabaseIdentifier:12757988] BioModels Database:BIOMD0000000939
dbId
176187
displayName
Activation of ATR in response to replication stress
edited
[InstanceEdit:176160] D'Eustachio, P, 2006年02月25日 17:41:28
eventOf
[Pathway:R-HSA-69481] G2/M Checkpoints - Homo sapiens
figure
[Figure:176321] /figures/ATR_loading.jpg
goBiologicalProcess
[GO_BiologicalProcess:7962] DNA replication
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-176175] Stalling of DNA replication fork and RPA binding - Homo sapiens
[Reaction:R-HSA-176250] Binding of ATR-ATRIP to the RPA-ssDNA complex - Homo sapiens
[Reaction:R-HSA-176101] Recruitment of Rad17-RFC complex to DNA - Homo sapiens
[Reaction:R-HSA-176264] Recruitment of the Rad9-Hus1-Rad1 complex to DNA - Homo sapiens
[Reaction:R-HSA-176318] Loading of claspin onto DNA during replication origin firing - Homo sapiens
[Reaction:R-HSA-176298] Activation of claspin - Homo sapiens
[Reaction:R-HSA-176116] Recruitment and activation of Chk1 - Homo sapiens
[Reaction:R-HSA-69604] Phosphorylation of CDC25A by CHEK1 - Homo sapiens
[Reaction:R-HSA-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2014年07月15日
literatureReference
[LiteratureReference:176216] Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Activation of ATR in response to replication stress
orthologousEvent
[Pathway:R-PFA-176187] Activation of ATR in response to replication stress - Plasmodium falciparum
[Pathway:R-SCE-176187] Activation of ATR in response to replication stress - Saccharomyces cerevisiae
[Pathway:R-SPO-176187] Activation of ATR in response to replication stress - Schizosaccharomyces pombe
[Pathway:R-DDI-176187] Activation of ATR in response to replication stress - Dictyostelium discoideum
[Pathway:R-CEL-176187] Activation of ATR in response to replication stress - Caenorhabditis elegans
[Pathway:R-DME-176187] Activation of ATR in response to replication stress - Drosophila melanogaster
[Pathway:R-GGA-176187] Activation of ATR in response to replication stress - Gallus gallus
[Pathway:R-XTR-176187] Activation of ATR in response to replication stress - Xenopus tropicalis
[Pathway:R-DRE-176187] Activation of ATR in response to replication stress - Danio rerio
[Pathway:R-SSC-176187] Activation of ATR in response to replication stress - Sus scrofa
[Pathway:R-BTA-176187] Activation of ATR in response to replication stress - Bos taurus
[Pathway:R-CFA-176187] Activation of ATR in response to replication stress - Canis familiaris
[Pathway:R-RNO-176187] Activation of ATR in response to replication stress - Rattus norvegicus
[Pathway:R-MMU-176187] Activation of ATR in response to replication stress - Mus musculus
releaseDate
2006年04月24日
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-176187
summation
[Summation:176245] Genotoxic stress caused by DNA damage or stalled replication...
updateTrackers
[UpdateTracker:9789131] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v38:[updateContainedRLE]
[UpdateTracker:9789840] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v37:[modifyText]
[UpdateTracker:9786466] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v49:[modifyText]
[UpdateTracker:9791681] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v27:[updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9789131] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v38:[updateContainedRLE]
[UpdateTracker:9789840] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v37:[modifyText]
[UpdateTracker:9786466] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v49:[modifyText]
[UpdateTracker:9791681] Update Tracker - [Pathway:176187] Activation of ATR in response to replication stress - v27:[updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-69481] G2/M Checkpoints
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