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Schema
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Reaction
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Entries
GSS:Mg2+ dimer synthesizes GSH
Show undefined attributes
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catalystActivity
[CatalystActivity:174399] glutathione synthase activity of GSS:Mg2+ dimer [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:174378] Jassal, Bijay, 2006年02月17日
crossReference
[DatabaseIdentifier:12611194] Rhea:13558
dbId
174394
displayName
GSS:Mg2+ dimer synthesizes GSH
edited
[InstanceEdit:1247945] Jassal, B, 2011年04月08日
eventOf
[Pathway:R-HSA-174403] Glutathione synthesis and recycling - Homo sapiens
followingEvent
[Reaction:R-HSA-176059] GST trimers transfer GS from GSH to luminal substrates - Homo sapiens
[Reaction:R-HSA-176054] GST dimers conjugate GSH with cytosolic substrates - Homo sapiens
[BlackBoxEvent:R-HSA-1247915] GSH translocates from cytosol to extracellular region - Homo sapiens
[Reaction:R-HSA-6785928] CHAC1,2 cleaves GSH to OPRO and CysGly - Homo sapiens
[Reaction:R-HSA-9753280] GSTs transfer GSH to NAPQI to form APAP-SG - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-174393] gGluCys [cytosol]
[SimpleEntity:R-ALL-29424] Gly [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1247901] Sequencing and expression of a cDNA for human glutathione synthetase
[LiteratureReference:5602985] Molecular basis of glutathione synthetase deficiency and a rare gene permutation event
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
GSS:Mg2+ dimer synthesizes GSH
gamma-glutamylcysteine combines with glycine to form glutathione
orthologousEvent
[Reaction:R-PFA-174394] GSS:Mg2+ dimer synthesizes GSH - Plasmodium falciparum
[Reaction:R-GGA-174394] GSS:Mg2+ dimer synthesizes GSH - Gallus gallus
[Reaction:R-MMU-174394] GSS:Mg2+ dimer synthesizes GSH - Mus musculus
[Reaction:R-SCE-174394] GSS:Mg2+ dimer synthesizes GSH - Saccharomyces cerevisiae
[Reaction:R-SPO-174394] GSS:Mg2+ dimer synthesizes GSH - Schizosaccharomyces pombe
[Reaction:R-DDI-174394] GSS:Mg2+ dimer synthesizes GSH - Dictyostelium discoideum
[Reaction:R-CEL-174394] GSS:Mg2+ dimer synthesizes GSH - Caenorhabditis elegans
[Reaction:R-DME-174394] GSS:Mg2+ dimer synthesizes GSH - Drosophila melanogaster
[Reaction:R-DRE-174394] GSS:Mg2+ dimer synthesizes GSH - Danio rerio
[Reaction:R-SSC-174394] GSS:Mg2+ dimer synthesizes GSH - Sus scrofa
[Reaction:R-BTA-174394] GSS:Mg2+ dimer synthesizes GSH - Bos taurus
[Reaction:R-CFA-174394] GSS:Mg2+ dimer synthesizes GSH - Canis familiaris
[Reaction:R-RNO-174394] GSS:Mg2+ dimer synthesizes GSH - Rattus norvegicus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-29450] GSH [cytosol]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent
[Reaction:R-HSA-174367] GCL ligates L-Glu to L-Cys - Homo sapiens
[Reaction:R-HSA-1247910] CNDP2:2Mn2+ dimer hydrolyses CysGly - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-1260991] Negative regulation by 'GSH [cytosol]'
regulationReference
[RegulationReference:9641341] Negative regulation by 'GSH [cytosol]' Patients with genetic defects in the gamma-glutamyl cycle
releaseDate
2005年06月13日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:351775] D'Eustachio, P, 2008年05月28日 08:30:54
revised
[InstanceEdit:5602271] Jassal, Bijay, 2014年06月23日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-174394
summation
[Summation:178803] In the second step in the formation of glutathione, gamma-gl...
systematicName
GSS:Mg2+ dimer synthesizes GSH
updateTrackers
[UpdateTracker:9789611] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v37:[addLiteratureReference, addRegulator, modifyText]
[UpdateTracker:9790721] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v33:[addInput]
[UpdateTracker:9786132] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v50:[addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9789611] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v37:[addLiteratureReference, addRegulator, modifyText]
[UpdateTracker:9790721] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v33:[addInput]
[UpdateTracker:9786132] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v50:[addLiteratureReference, modifyText]
(precedingEvent)
[Reaction:R-HSA-9753280] GSTs transfer GSH to NAPQI to form APAP-SG
[Reaction:R-HSA-176059] GST trimers transfer GS from GSH to luminal substrates
[Reaction:R-HSA-176054] GST dimers conjugate GSH with cytosolic substrates
[BlackBoxEvent:R-HSA-1247915] GSH translocates from cytosol to extracellular region
[Reaction:R-HSA-6785928] CHAC1,2 cleaves GSH to OPRO and CysGly
(normalReaction)
[FailedReaction:R-HSA-5602901] Defective GSS does not synthesize GSH
(hasEvent)
[Pathway:R-HSA-174403] Glutathione synthesis and recycling
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