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Schema
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Reaction
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Entries
GCL ligates L-Glu to L-Cys
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authored
[InstanceEdit:174378] Jassal, Bijay, 2006年02月17日
catalystActivity
[CatalystActivity:174398] glutamate-cysteine ligase activity of GCL [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:174378] Jassal, Bijay, 2006年02月17日
crossReference
[DatabaseIdentifier:12611198] Rhea:13286
dbId
174367
displayName
GCL ligates L-Glu to L-Cys
edited
[InstanceEdit:1247945] Jassal, B, 2011年04月08日
eventOf
[Pathway:R-HSA-174403] Glutathione synthesis and recycling - Homo sapiens
followingEvent
[Reaction:R-HSA-174394] GSS:Mg2+ dimer synthesizes GSH - Homo sapiens
[Reaction:R-HSA-1247922] GGCT transforms gGluCys to OPRO - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-111707] L-Cys [cytosol]
[SimpleEntity:R-ALL-29404] L-Glu [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1247938] Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues
[LiteratureReference:1247925] Expression and purification of human gamma-glutamylcysteine synthetase
maxDepth
1
modified
[InstanceEdit:11001822] Weiser, Joel, 2025年08月28日
name
GCL ligates L-Glu to L-Cys
Glutamate and cysteine combine
orthologousEvent
[Reaction:R-MMU-174367] GCL ligates L-Glu to L-Cys - Mus musculus
[Reaction:R-SPO-174367] GCL ligates L-Glu to L-Cys - Schizosaccharomyces pombe
[Reaction:R-CEL-174367] GCL ligates L-Glu to L-Cys - Caenorhabditis elegans
[Reaction:R-DME-174367] GCL ligates L-Glu to L-Cys - Drosophila melanogaster
[Reaction:R-XTR-174367] GCL ligates L-Glu to L-Cys - Xenopus tropicalis
[Reaction:R-SSC-174367] GCL ligates L-Glu to L-Cys - Sus scrofa
[Reaction:R-BTA-174367] GCL ligates L-Glu to L-Cys - Bos taurus
[Reaction:R-CFA-174367] GCL ligates L-Glu to L-Cys - Canis familiaris
[Reaction:R-RNO-174367] GCL ligates L-Glu to L-Cys - Rattus norvegicus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-174393] gGluCys [cytosol]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent
[Reaction:R-HSA-1247935] OPLAH hydrolyses OPRO to L-Glu - Homo sapiens
[Reaction:R-HSA-1247910] CNDP2:2Mn2+ dimer hydrolyses CysGly - Homo sapiens
[Reaction:R-HSA-9753944] ACY1:Zn2+ dimer deacetylates NAC to L-Cys - Homo sapiens
releaseDate
2005年06月13日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:351775] D'Eustachio, P, 2008年05月28日 08:30:54
revised
[InstanceEdit:5602271] Jassal, Bijay, 2014年06月23日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-174367
summation
[Summation:178811] The first step in the formation of glutathione is the ligati...
systematicName
GCL ligates L-Glu, L-Cys to gGluCys
updateTrackers
[UpdateTracker:9789690] Update Tracker - [Reaction:174367] GCL ligates L-Glu to L-Cys - v37:[addLiteratureReference, modifyText]
[UpdateTracker:9786137] Update Tracker - [Reaction:174367] GCL ligates L-Glu to L-Cys - v50:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9789690] Update Tracker - [Reaction:174367] GCL ligates L-Glu to L-Cys - v37:[addLiteratureReference, modifyText]
[UpdateTracker:9786137] Update Tracker - [Reaction:174367] GCL ligates L-Glu to L-Cys - v50:[modifyText]
(normalReaction)
[FailedReaction:R-HSA-5602892] Defective GCLC does not ligate L-Glu to L-Cys
(hasEvent)
[Pathway:R-HSA-174403] Glutathione synthesis and recycling
(precedingEvent)
[Reaction:R-HSA-174394] GSS:Mg2+ dimer synthesizes GSH
[Reaction:R-HSA-1247922] GGCT transforms gGluCys to OPRO
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