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Entries
NF-kappa-B complex is transported from cytosol to nucleus
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authored
[InstanceEdit:450362] Shamovsky, V, 2009年12月16日
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created
[InstanceEdit:168183] Gillespie, ME, 2005年11月10日 16:33:34
dbId
168166
displayName
NF-kappa-B complex is transported from cytosol to nucleus
edited
[InstanceEdit:3465604] Shamovsky, V, 2013年05月17日
eventOf
[Pathway:R-HSA-933542] TRAF6 mediated NF-kB activation - Homo sapiens
[Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation - Homo sapiens
followingEvent
[Reaction:R-HSA-9909622] NFKB_complex binding to CD274 gene - Homo sapiens
input
[Complex:R-HSA-168155] NFKB1(1-433), NFKB2(1-454):RELA [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:177888] Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex
[LiteratureReference:202538] The two NF-kappaB activation pathways and their role in innate and adaptive immunity
[LiteratureReference:202509] Ubiquitin signalling in the NF-kappaB pathway
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
NF-kappa-B complex is transported from cytosol to nucleus
orthologousEvent
[Reaction:R-GGA-433823] Released NFkB complex migrates to the nucleus and turns on transcription - Gallus gallus
[Reaction:R-DME-168166] NF-kappa-B complex is transported from cytosol to nucleus - Drosophila melanogaster
[Reaction:R-GGA-168166] NF-kappa-B complex is transported from cytosol to nucleus - Gallus gallus
[Reaction:R-DRE-168166] NF-kappa-B complex is transported from cytosol to nucleus - Danio rerio
[Reaction:R-SSC-168166] NF-kappa-B complex is transported from cytosol to nucleus - Sus scrofa
[Reaction:R-BTA-168166] NF-kappa-B complex is transported from cytosol to nucleus - Bos taurus
[Reaction:R-CFA-168166] NF-kappa-B complex is transported from cytosol to nucleus - Canis familiaris
[Reaction:R-RNO-168166] NF-kappa-B complex is transported from cytosol to nucleus - Rattus norvegicus
[Reaction:R-MMU-168166] NF-kappa-B complex is transported from cytosol to nucleus - Mus musculus
output
[Complex:R-HSA-177673] NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm]
precedingEvent
[Reaction:R-HSA-168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - Homo sapiens
[Reaction:R-HSA-9773803] Active IKBKB phosphorylates NF-kappa-B inhibitor - Homo sapiens
regulatedBy
[PositiveRegulation:R-HSA-879381] Positive regulation by 'AGER ligands:AGER [plasma membrane]'
regulationReference
[RegulationReference:9641624] Positive regulation by 'AGER ligands:AGER [plasma membrane]' Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB
releaseDate
2010年12月14日
requiredInputComponent
[Complex:R-HSA-157689] Nuclear Pore Complex (NPC) [nuclear envelope] - Homo sapiens
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2023355] D'Eustachio, P, 2011年12月07日
[InstanceEdit:2129340] Upton, JW, Mocarski, ES, 2012年02月19日
[InstanceEdit:2603254] Napetschnig, Johanna, 2012年11月16日
[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012年11月13日
[InstanceEdit:3597627] Jin, Lei, 2013年05月21日
[InstanceEdit:3597624] Wu, Jiaxi, 2013年05月21日
[InstanceEdit:9773242] de Martin, R, 2022年05月04日
revised
[InstanceEdit:442879] Shamovsky, V, 2009年09月29日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-168166
summation
[Summation:433791] NFkB is a family of transcription factors that play pivotal ...
[Summation:879478] Though the signaling cascade is unclear, several pieces of e...
updateTrackers
[UpdateTracker:9779356] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v65:[removeRegulator]
[UpdateTracker:9775871] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v78:[addSummation]
[UpdateTracker:9790101] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v35:[modifyText]
[UpdateTracker:9774732] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v81:[modifyText]
[UpdateTracker:9790876] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v32:[addLiteratureReference, add_removeSummation]
[UpdateTracker:9788281] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v43:[modifyText]
[UpdateTracker:9788066] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v44:[addRegulator]
[UpdateTracker:9790264] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v34:[addRegulator]
Referrals
(updatedInstance)
[UpdateTracker:9779356] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v65:[removeRegulator]
[UpdateTracker:9775871] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v78:[addSummation]
[UpdateTracker:9790101] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v35:[modifyText]
[UpdateTracker:9774732] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v81:[modifyText]
[UpdateTracker:9790876] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v32:[addLiteratureReference, add_removeSummation]
[UpdateTracker:9788281] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v43:[modifyText]
[UpdateTracker:9788066] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v44:[addRegulator]
[UpdateTracker:9790264] Update Tracker - [Reaction:168166] NF-kappa-B complex is transported from cytosol to nucleus - v34:[addRegulator]
(precedingEvent)
[Reaction:R-HSA-9909622] NFKB_complex binding to CD274 gene
(hasEvent)
[Pathway:R-HSA-445989] TAK1-dependent IKK and NF-kappa-B activation
[Pathway:R-HSA-933542] TRAF6 mediated NF-kB activation
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