Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
Active IKK Complex phosphorylates NF-kappa-B inhibitor
Show undefined attributes
Go to Details
catalystActivity
[CatalystActivity:450351] protein serine/threonine kinase activity of IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:168183] Gillespie, ME, 2005年11月10日 16:33:34
dbId
168140
displayName
Active IKK Complex phosphorylates NF-kappa-B inhibitor
edited
[InstanceEdit:450363] Shamovsky, V, 2009年12月16日
eventOf
[Pathway:R-HSA-1810476] RIP-mediated NFkB activation via ZBP1 - Homo sapiens
followingEvent
[Reaction:R-HSA-9604480] NFkB complex translocates from the cytosol to the nucleus - Homo sapiens
[Reaction:R-HSA-168166] NF-kappa-B complex is transported from cytosol to nucleus - Homo sapiens
input
4 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-168130] NFkB inhibitor:NFkB complex [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:177888] Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex
[LiteratureReference:202505] Regulation and function of IKK and IKK-related kinases
[LiteratureReference:9630958] Double phosphorylation-induced structural changes in the signal-receiving domain of I?B? in complex with NF-?B
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
Active IKK Complex phosphorylates NF-kappa-B inhibitor
orthologousEvent
[Reaction:R-DME-168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - Drosophila melanogaster
[Reaction:R-SSC-168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - Sus scrofa
[Reaction:R-BTA-168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - Bos taurus
[Reaction:R-CFA-168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - Canis familiaris
[Reaction:R-RNO-168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - Rattus norvegicus
[Reaction:R-MMU-168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - Mus musculus
output
4 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-168155] NFKB1(1-433), NFKB2(1-454):RELA [cytosol]
[DefinedSet:R-HSA-177678] Phospho-NF-kappaB Inhibitor [cytosol]
precedingEvent
[Reaction:R-HSA-168910] RIP1 facilitates IKK complex phosphorylation - Homo sapiens
[Reaction:R-HSA-168184] Activated TAK1 mediates phosphorylation of the IKK Complex - Homo sapiens
[Reaction:R-HSA-933530] Activation of IKK by MEKK1 - Homo sapiens
[Reaction:R-HSA-9630923] NF-kappa-B inhibitor binds NF-kappa-B complex - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-8952695] Negative regulation by 'NKIRAS [cytosol]'
regulationReference
[RegulationReference:9641502] Negative regulation by 'NKIRAS [cytosol]' KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes
releaseDate
2010年03月16日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2023355] D'Eustachio, P, 2011年12月07日
[InstanceEdit:2129340] Upton, JW, Mocarski, ES, 2012年02月19日
[InstanceEdit:2603254] Napetschnig, Johanna, 2012年11月16日
[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012年11月13日
revised
[InstanceEdit:442879] Shamovsky, V, 2009年09月29日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-168140
summation
[Summation:450273] In human, IkBs (NFKBIA, NFKBIB or NFKBIE) are inhibitory pro...
systematicName
Activated IKK Complex phosphorylates IkBs:NFkB
updateTrackers
[UpdateTracker:9788855] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v40:[modifyText]
[UpdateTracker:9781856] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v60:[addRegulator]
[UpdateTracker:9774822] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v81:[modifyText]
[UpdateTracker:9791005] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v32:[addLiteratureReference, add_removeCatalystActivity, add_removeSummation]
[UpdateTracker:9777883] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v68:[addLiteratureReference]
[UpdateTracker:9775251] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v80:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9788855] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v40:[modifyText]
[UpdateTracker:9781856] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v60:[addRegulator]
[UpdateTracker:9774822] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v81:[modifyText]
[UpdateTracker:9791005] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v32:[addLiteratureReference, add_removeCatalystActivity, add_removeSummation]
[UpdateTracker:9777883] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v68:[addLiteratureReference]
[UpdateTracker:9775251] Update Tracker - [Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor - v80:[modifyText]
(hasEvent)
[Pathway:R-HSA-1810476] RIP-mediated NFkB activation via ZBP1
[Pathway:R-HSA-933542] TRAF6 mediated NF-kB activation
(precedingEvent)
[Reaction:R-HSA-9604480] NFkB complex translocates from the cytosol to the nucleus
[Reaction:R-HSA-168166] NF-kappa-B complex is transported from cytosol to nucleus
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル