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Entries
Activation of NF-kappaB in B cells
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authored
[InstanceEdit:1168647] May, B, 2011年01月03日
compartment
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
[Compartment:876] plasma membrane
created
[InstanceEdit:1169093] May, B, 2011年01月11日
crossReference
[DatabaseIdentifier:12758080] BioModels Database:BIOMD0000000243
[DatabaseIdentifier:12757942] BioModels Database:BIOMD0000000407
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12757928] BioModels Database:BIOMD0000000477
dbId
1169091
displayName
Activation of NF-kappaB in B cells
edited
[InstanceEdit:1168647] May, B, 2011年01月03日
eventOf
[Pathway:R-HSA-1168372] Downstream signaling events of B Cell Receptor (BCR) - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-1168373] PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine - Homo sapiens
[BlackBoxEvent:R-HSA-1168635] PRKCB (PKC-beta) phosphorylates CARMA1 - Homo sapiens
[Reaction:R-HSA-1168644] CARMA1 recruits MALT1 and BCL10 forming CBM Complex - Homo sapiens
[BlackBoxEvent:R-HSA-1168637] CARMA1:BCL10:MALT1 complex recruits TAK1 and IKK - Homo sapiens
[Reaction:R-HSA-1168641] TAK1 associated with the CBM complex phosphorylates IKKbeta - Homo sapiens
[Reaction:R-HSA-1168638] Activated IKK phosphorylates I-kappaB - Homo sapiens
[Reaction:R-HSA-1168642] SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB - Homo sapiens
[BlackBoxEvent:R-HSA-1168643] SCF-beta-TrCP ubiquitinylates IkB - Homo sapiens
[BlackBoxEvent:R-HSA-1168640] Ubiquitinated IkB is degraded - Homo sapiens
[BlackBoxEvent:R-HSA-1168633] NF-kappaB translocates from the cytosol to the nucleus - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1169032] Activation of purified human protein kinase C alpha and beta I isoenzymes in vitro by Ca2+, phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate
[LiteratureReference:1169052] Phosphorylation of the CARMA1 linker controls NF-kappaB activation
[LiteratureReference:1168956] CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation
[LiteratureReference:571311] PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1
[LiteratureReference:208156] TAK1 is a ubiquitin-dependent kinase of MKK and IKK
[LiteratureReference:1168538] Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate
[LiteratureReference:1168550] Peptides corresponding to the N and C termini of IkappaB-alpha, -beta, and -epsilon as probes of the two catalytic subunits of IkappaB kinase, IKK-1 and IKK-2
[LiteratureReference:1168554] All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex
[LiteratureReference:1169573] Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B
[LiteratureReference:1169542] A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B
[LiteratureReference:1169584] Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway
[LiteratureReference:1169570] Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B
[LiteratureReference:1169520] Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B
[LiteratureReference:1169546] Inactivation of NF-kappa B inhibitor I kappa B alpha: ubiquitin-dependent proteolysis and its degradation product
[LiteratureReference:1168544] Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination
[LiteratureReference:208326] Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway
[LiteratureReference:1169600] Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor
[LiteratureReference:1169574] Cytoplasmic retention, DNA binding and processing of the NF-kappa B p50 precursor are controlled by a small region in its C-terminus
[LiteratureReference:1169453] Analysis of nucleocytoplasmic shuttling of NF kappa B proteins in human leukocytes
[LiteratureReference:1169528] NF-kappaB p52, RelB and c-Rel are transported into the nucleus via a subset of importin alpha molecules
maxDepth
2
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
Activation of NF-kappaB in B cells
orthologousEvent
[Pathway:R-XTR-1169091] Activation of NF-kappaB in B cells - Xenopus tropicalis
[Pathway:R-MMU-1169091] Activation of NF-kappaB in B cells - Mus musculus
[Pathway:R-RNO-1169091] Activation of NF-kappaB in B cells - Rattus norvegicus
[Pathway:R-CFA-1169091] Activation of NF-kappaB in B cells - Canis familiaris
[Pathway:R-BTA-1169091] Activation of NF-kappaB in B cells - Bos taurus
[Pathway:R-SSC-1169091] Activation of NF-kappaB in B cells - Sus scrofa
[Pathway:R-DRE-1169091] Activation of NF-kappaB in B cells - Danio rerio
[Pathway:R-GGA-1169091] Activation of NF-kappaB in B cells - Gallus gallus
[Pathway:R-DME-1169091] Activation of NF-kappaB in B cells - Drosophila melanogaster
[Pathway:R-CEL-1169091] Activation of NF-kappaB in B cells - Caenorhabditis elegans
[Pathway:R-DDI-1169091] Activation of NF-kappaB in B cells - Dictyostelium discoideum
[Pathway:R-SPO-1169091] Activation of NF-kappaB in B cells - Schizosaccharomyces pombe
[Pathway:R-SCE-1169091] Activation of NF-kappaB in B cells - Saccharomyces cerevisiae
releaseDate
2012年03月13日
releaseStatus
UPDATED
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2108988] Wienands, J, 2012年02月11日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-1169091
summation
[Summation:1169603] DAG and calcium activate protein kinase C beta (PKC-beta, Ko...
Referrals
(hasEvent)
[Pathway:R-HSA-1168372] Downstream signaling events of B Cell Receptor (BCR)
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