Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
NegativeGeneExpressionRegulation
>
Entries
Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]'
Show undefined attributes
Go to Details
activity
[GO_MolecularFunction:2266139] DNA-binding transcription repressor activity, RNA polymerase II-specific
created
[InstanceEdit:9909554] May, Bruce, 2024年05月14日
dbId
9909568
displayName
Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]'
regulatedEntity
[BlackBoxEvent:R-HSA-879798] Expression of DEC1 (BHLHE40, BHLHB2) - Homo sapiens
[BlackBoxEvent:R-HSA-879770] Expression of DEC2 (BHLHE41, BHLHB3) - Homo sapiens
[BlackBoxEvent:R-HSA-9909561] Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-1 (PER1) - Homo sapiens
regulator
[Complex:R-HSA-9909555] BHLHE40 dimer [nucleoplasm]
schemaClass
NegativeGeneExpressionRegulation
Referrals
(regulation)
[RegulationReference:9909562] Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]' Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1
[RegulationReference:9909559] Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]' DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
(regulatedBy)
[BlackBoxEvent:R-HSA-879798] Expression of DEC1 (BHLHE40, BHLHB2)
[BlackBoxEvent:R-HSA-879770] Expression of DEC2 (BHLHE41, BHLHB3)
[BlackBoxEvent:R-HSA-9909561] Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-1 (PER1)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル