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Schema
>
BlackBoxEvent
>
Entries
Expression of DEC2 (BHLHE41, BHLHB3)
Show undefined attributes
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authored
[InstanceEdit:879784] May, B, 2010年06月18日
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:879757] May, B, 2010年06月23日
dbId
879770
displayName
Expression of DEC2 (BHLHE41, BHLHB3)
edited
[InstanceEdit:879784] May, B, 2010年06月18日
eventOf
[Pathway:R-HSA-1368108] BMAL1:CLOCK,NPAS2 activates circadian expression - Homo sapiens
inferredFrom
[BlackBoxEvent:R-MMU-879716] Expression of Dec2 (Bhlhe41, Bhlhb3) - Mus musculus
input
[EntityWithAccessionedSequence:R-HSA-5641212] BHLHE41 gene [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
true
literatureReference
[LiteratureReference:1368871] Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins
[LiteratureReference:9909541] DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
maxDepth
1
modified
[InstanceEdit:9953423] May, Bruce, 2025年06月02日
name
Expression of DEC2 (BHLHE41, BHLHB3)
output
[EntityWithAccessionedSequence:R-HSA-879703] BHLHE41 [nucleoplasm]
precedingEvent
[Reaction:R-HSA-5663105] p-S90-BMAL1:p-T451,T461-CLOCK binds BHLHE41 (DEC2) gene - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
regulatedBy
[PositiveGeneExpressionRegulation:R-HSA-879843] Positive gene expression regulation by 'p-S90-BMAL1:p-T451,T461-CLOCK:BHLHE41 gene [nucleoplasm]'
[NegativeGeneExpressionRegulation:9909568] Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]'
regulationReference
[RegulationReference:9642601] Positive gene expression regulation by 'p-BMAL1:p-CLOCK,NPAS2:BHLHE41 gene [nucleoplasm]' Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system
[RegulationReference:9909559] Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]' DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
releaseDate
2010年09月21日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:422151] D'Eustachio, P, 2009年05月26日 22:13:22
[InstanceEdit:879756] Albrecht, Urs, 2010年06月23日
[InstanceEdit:879726] Kay, SA, 2010年06月23日
[InstanceEdit:879790] Hirota, T, 2010年06月23日
[InstanceEdit:879786] Delaunay, F, 2010年06月23日
[InstanceEdit:9953422] Albrecht, Urs, 2025年03月07日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-879770
summation
[Summation:879751] The DEC2 (BHLHE41, BHLHB3) gene is transcribed to yield mRNA...
updateTrackers
[UpdateTracker:9786974] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v46:[modifyText]
[UpdateTracker:9953555] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v93:[removeLiteratureReference, removeRegulator]
[UpdateTracker:9785917] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v51:[addInput]
[UpdateTracker:9789249] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v38:[addLiteratureReference]
[UpdateTracker:9785458] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v52:[add_removeRegulator]
Referrals
(updatedInstance)
[UpdateTracker:9786974] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v46:[modifyText]
[UpdateTracker:9953555] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v93:[removeLiteratureReference, removeRegulator]
[UpdateTracker:9785917] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v51:[addInput]
[UpdateTracker:9789249] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v38:[addLiteratureReference]
[UpdateTracker:9785458] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v52:[add_removeRegulator]
(hasEvent)
[Pathway:R-HSA-1368108] BMAL1:CLOCK,NPAS2 activates circadian expression
(inferredTo)
[BlackBoxEvent:R-MMU-879716] Expression of Dec2 (Bhlhe41, Bhlhb3)
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